Extreme Outlier Analysis Identifies Occult Mitogen-Activated Protein Kinase Pathway Mutations in Patients With Low-Grade Serous Ovarian Cancer [BIOLOGY OF NEOPLASIA]

Conclusion
Alterations affecting the mitogen-activated protein kinase pathway are present in the majority of patients with LGS ovarian cancer. Next-generation sequencing analysis revealed deletions and fusions that are not detected by older sequencing approaches. These findings, coupled with the observation that a subset of patients with recurrent LGS ovarian cancer experienced dramatic and durable responses to MEK inhibitor therapy, support additional clinical studies of MEK inhibitors in this disease.

Source: Journal of Clinical Oncology - November 25, 2015 Category: Cancer & Oncology Authors: Grisham, Sylvester, Won, McDermott, DeLair, Ramirez, Yao, Shen, Dao, Bogomolniy, Makker, Sala, Soumerai, Hyman, Socci, Viale, Gershenson, Farley, Levine, Rosen, Berger, Spriggs, Aghajanian, Solit, Iyer Tags: Translational Oncology, Signal Transduction, Growth Factors & Receptor, Oncogenes BIOLOGY OF NEOPLASIA Source Type: research