Optimal Threshold and Time of Absolute Lymphocyte Count Assessment for Outcome Prediction after Bone Marrow Transplantation

The recovery pace of absolute lymphocyte count (ALC) is prognostic after hematopoietic stem cell transplantation. Previous studies have evaluated a wide range of ALC cutoffs and time points for predicting outcomes. We aimed to determine the optimal ALC value for outcome prediction after bone marrow transplantation (BMT). A total of 518 patients who underwent BMT for acute leukemia or myelodysplastic syndrome between 1999 and 2010 were divided into a training set and a test set to assess the prognostic value of ALC on days 30, 60, 90, 120, 180, as well as the first post-transplantation day of an ALC of 100, 200, 300, 400, 500, and 1000/μL.

Source: Biology of Blood and Marrow Transplantation - October 30, 2015 Category: Hematology Authors: Ulas D. Bayraktar, Denái R. Milton, Michele Guindani, Gabriela Rondon, Julianne Chen, Gheath Al-Atrash, Katayoun Rezvani, Richard Champlin, Stefan O. Ciurea Source Type: research