A144

Publication date: November 2015 Source:European Journal of Cancer Supplements, Volume 13, Issue 1 Author(s): T. Khramova, V. Varaksin, L. Beduleva, I. Menshikov Existing methods for the preoperative detection of metastases in thyroid cancer have low efficiency and highly invasive. Therefore, the searches for laboratory markers that will indicate the presence of metastases including hidden with high reliability in cancer of the thyroid gland are relevant. Immune system is one of the key mechanisms for regulation of tissue proliferation. Autoreactive lymphocytes restrict the growth and proliferation of tissues. In turn autoreactive lymphocytes are controlled by idiotypic lymphocytes. Abnormalities in the regulation system can be the cause of tumor growth, such as excess activity of anti-idiotypic lymphocytes. Previously we conducted a comparative analysis of the level of autoantibodies to various antigens (thyroglobulin, thyroid stimulating hormone receptor, native DNA, anionic proteins vascular endothelium), as well as anti-idiotypic antibodies to thyroglobulin in thyroid cancer patients with metastases and without metastases. Significant differences between investigated groups were found in the level of anti-idiotypic antibodies against antibodies to thyroglobulin. Therefore, the aim of this study was to analyze the feasibility of using anti-idiotypic antibodies against antibodies to thyroglobulin as a marker of metastatic thyroid cancer. All studied patients with...
Source: European Journal of Cancer Supplements - Category: Cancer & Oncology Source Type: research