P43

Conclusion In serum of control (healthy) group, cystatin C concentration is significantly higher than cystatin SN level in serum, tears and intraocular fluid. The reverse correlation was revealed between the level of these inhibitors in serum, that is suggested their possible interaction. In melanoma patients the reciprocal changes in cystatin C and cystatin SN were shown: increased cystatin C and decreased cystatin SN level in all biological fluids studied. On the basis of cystatins distribution in biological fluids of patients one can suggest their involvement in pathological process as system reaction of organism on tumor development.
Source: European Journal of Cancer Supplements - Category: Cancer & Oncology Source Type: research