P132

Conclusions 1.It was established that in the pathogenesis of choroidal melanoma, local Inflammation plays an important role as evidenced by a significant high concentration of IL-6, IL-8 due to lower levels of IL-4 and expressed immune disorders, cell destruction, as evidenced by significantly high level of AAB to Ag of nDNA, compared with the control group. 2.Use of lacrimal liquid is suitable for the study of the inflammation, immune disorders and cell destruction at the local level in patients with choroidal melanoma. 3.Significant increase in IL-6 level in lacrimal liquid was observed for all stages of choroidal melanoma, however, it was more pronounced in early stages (T1–T2), than in later stages (T3–T4). 4.A significant increase in IL-10 may indicate the severity of the local immunosuppression induced by tumor growth in the mechanisms of choroidal melanoma. A significant positive relationship between the concentrations of IL-4, IL-6, IL-8, IL-10, AAB to Ag of nDNA in the lacrimal liquids of eye and paired “healthy” eye was found in patients with choroidal melanoma.
Source: European Journal of Cancer Supplements - Category: Cancer & Oncology Source Type: research