Endocrine experts call for more research into leading cause of infertility
(The Endocrine Society) More research is needed to better understand polycystic ovary syndrome -- one of the leading causes of infertility, according to the Scientific Statement issued by the Endocrine Society.
Authors: Anderson RC, Newton CL, Anderson RA, Millar RP Abstract The gonadotropin receptors, luteinising hormone receptor, and follicle-stimulating hormone receptor, play a central role in governing reproductive competency/fertility. Gonadotropin hormone analogues have been utilised clinically for decades, in assisted reproductive therapies, and in the treatment of various infertility disorders. While these treatments are effective, the clinical protocols demand multiple injections, and the hormone preparations can lack uniformity and stability. The past two decades have seen a drive to develop chimeric and modifie...
Publication date: Available online 17 April 2018Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Seema PatelAbstractPolycystic ovary syndrome (PCOS) is an endocrine disorder, afflicting females of reproductive age. This syndrome leads to infertility, insulin resistance, obesity, and cardiovascular problems, including a litany of other health issues. PCOS is a polygenic, polyfactorial, systemic, inflammatory, dysregulated steroid state, autoimmune disease, manifesting largely due to lifestyle errors. The advent of biochemical tests and ultrasound scanning has enabled the detection of PCOS in the a...
ConclusionsThe processes related to the differentially expressed proteins play important roles in fecundity and fecundability. The present study may reveal the cause of various endometrial aberrations as a limiting factor for achieving pregnancy in PCOS women.
ConclusionAccording to these results, although PCOS may have negative effects in different aspects of suffering people, it cannot singly reduce social support and marital satisfaction among infertile women; and infertility can be more important than PCOS for infertile women.
ConclusionThere was a weak, positive relationship between personality type and cortisol in polycystic ovarian syndrome, and the cortisol level was found to be higher in neurotically inclined and psychotically inclined personalities than in normal personalities with PCOS.
Publication date: Available online 6 January 2018Source: Middle East Fertility Society JournalAuthor(s): Kamal M. Zahran, Waleed A. Mostafa, Ahmed M. Abbas, Mansour A. Khalifa, Gamal H. SayedAbstractObjectiveTo compare the effect of adjunctive use of cabergoline with clomiphene citrate (CC) in infertile polycystic ovarian syndrome (PCOS) patients with normal prolactin level.Study designA randomized clinical trial (NCT 02644304).SettingAssiut University Hospital, Assiut, Egypt.Materials and methodsInfertile euprolactinemic PCOS patient were recruited and randomized in a 1:1 ratio to CC plus cabergoline or CC alone. All pati...
ConclusionThe findings show decreased serum Se and Zn levels in the PCOS patients as compared to the controls. Additionally, the results confirm the correlation between zinc and insulin resistance.
ConclusionThis study showed that the pregnancy rate achieved with letrozole/estradiol valerate combination was significantly higher than with letrozole alone. This was attributed to the improvement of endometrial thickness by estradiol valerate.
ConclusionFindings of this study showed that risk factors of recurrent abortion, TPO-Ab and uterine leiomyoma have significant importance in pregnant patients undergoing ART.
ConclusionLack of awareness and compulsion to fulfil socially expected role of a woman, women suffering from PCOS, in this part of India, aim only at becoming pregnant (in case of married women) and normalising their monthly periods (in case of unmarried females). However, there is need to spread awareness about PCOS and encouraging women to adopt knowledge, attitude and practice approach to manage this disease.