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Infertile worms resist infection-induced neurodegeneration

(Duke University) Mounting evidence points to a link between infections, the immune response, and neurodegenerative diseases. New findings from Duke appearing in the Journal of Biological Chemistry show that infection with pathogenic bacteria causes neurodegeneration in the worm C. elegans, creating neural changes that are hallmarks of illnesses like Alzheimer's disease in humans. The study also yielded a big surprise: sterile animals appeared to be protected from neurodegeneration.
Source: EurekAlert! - Medicine and Health - Category: Global & Universal Source Type: news

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Men and women follow the Wheat Belly lifestyle and can undergo important and sometime startling hormonal changes. Though results vary with stage of life—young adults, middle-aged, older—there are a variety of hormonal changes that women and men typically experience, some in concert, others independently. Such hormonal shifts can be powerful and part of the health-restoring menu of changes that develop with this lifestyle. They can even improve a relationship in a number of ways, both physically and emotionally, especially if we weave in some of the newer Wheat Belly/Undoctored concepts and practices such as oxy...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Lifestyle estradiol estrogen hormonal hormones Inflammation low-carb oxytocin testosterone Thyroid Weight Loss Source Type: blogs
Abstract Mitochondria play a fundamental role during development of the female germline. They are fragmented, round and small. Despite these characteristics suggesting that they are inactive, there is accumulating evidence that mitochondrial dysfunctions are a major cause of infertility and generation of aneuploidies in humans. In addition, mitochondria and their own genomes (mitochondrial DNA - mtDNA) may become damaged with time, which might be one reason why aging leads to infertility. As a result, mitochondria have been proposed as an important target for evaluating oocyte and embryo quality, and developing tr...
Source: Cell Biology International - Category: Cytology Authors: Tags: Cell Biol Int Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusion MO has emerged as a good source of traditional medicines. Some uses of this plant in traditional medicines have been validated by pharmacological investigations. However, the molecular mechanism, structure-activity relationship, and potential synergistic and antagonistic effects of its multi-components such as polysaccharides, oligosaccharides, anthraquinones and iridoid glycosides need to be further elucidated, and the structural feature of polysaccharides also need to be further clarified. Sophisticated analytical technologies should be developed to comprehensively evaluate the quality of MO based on HPLC-fing...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
As The Author of Minding Our Elders: Caregivers Share Their Personal Stories, I'm honored to be chosen to be part AlzAuthors. This post is courtesy of AlzAuthors. Read through for some incredible deals on ebooks written by authors who've been where you are. MOE is among the books on sale. All are $2.99 or less. November is National Caregiver Appreciation Month, a time to recognize the long hours, sacrifice, and love all caregivers bring to the task of caring for a loved one with dementia or any long-term illness. In honor of their efforts, AlzAuthors is hosting an eBook sale and giveaway! This is a terrific way f...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
Calcium and integrin-binding protein 1 (CIB1) is an EF-hand calcium binding protein, which is involved in many cellular processes, including calcium signaling, cell survival and proliferation, cell migration, cell adhesion and apoptosis. A number of studies have found that CIB1 is ubiquitously expressed and is related to various human diseases, such as cancer, Alzheimer ’s disease (AD), cardiac hypertrophy and male infertility. The mechanism of CIB1 in human diseases is still not clear, although multiple functions of CIB1 are modulated by interacting with numerous interacting partners. As a calcium binding protein, t...
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
Publication date: 5 October 2017 Source:Journal of Hazardous Materials, Volume 339 Author(s): Sumit Sarkar, Ratan Das Glyphosate [N-phosphono-methylglycine (PMG)] is the most used herbicide worldwide and it has been reported very recently that Glyphosate is very harmful and can produce lots of diseases such as alzheimer and parkinson’s disease, depression, cancer, infertility including genotoxic effects. As it is mostly present in stable water body and ground water system, its detection and removal is very important. Here, we have shown a fluorescence technique for the removal of glyphosate from water using chemical...
Source: Journal of Hazardous Materials - Category: Environmental Health Source Type: research
This study shows that lifespan-extending conditions can slow molecular changes associated with an epigenetic clock in mice livers. Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions Age-associated epigenetic changes are implicated in aging. Notably, age-associated DNA methylation changes comprise a so-called aging "clock", a robust biomarker of aging. However, while genetic, dietary and drug interventions can extend lifespan, their impact on the epigenome is uncharacterised. To fill this knowledge gap, we defined...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
CONCLUSIONS: Overall, the literature data reviewed here provides a strong foundation for further characterization of molecular and microbial drivers of PD and of several female-prevalent systemic diseases, highlighting the possible importance of a good oral condition in preventing or attenuating women's systemic diseases. PMID: 28277873 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
I admit it. I have been MIA in the blogging world for the past six months.Mea culpa.There is a good reason. I am working in a neurobiology lab at the local university. We are researching ways to stop or slow the progression of Alzheimer's and other neurodegenerative disorders. I love it. After a decade of doom and gloom writing about the out-of-control biotechnology sector, I needed a change. One where I was actively contributing to positive research.I haven't totally abandoned writing though. Here is a teaser from my latest at theNational Catholic Register:I ’ve spent the last decade writing and speaking about the r...
Source: Mary Meets Dolly - Category: Genetics & Stem Cells Tags: Biotechnology Source Type: blogs
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