Glomerular expression of matrix metalloproteinases in AL-amyloidosis and association with renal function at the time of kidney biopsy.

CONCLUSION: The findings of this study show increased glomerular expression of MMP-1 and MMP-3 in patients with AL-amyloidosis which is associated with worse renal function at the time of the kidney biopsy. Our results suggest an important role for MMP-1 and MMP-3 in the pathogenesis of renal damage in AL-amyloidosis.
PMID: 26587779 [PubMed - as supplied by publisher]

Source: Clinical Nephrology - November 20, 2015 Category: Urology & Nephrology Authors: Charitaki E, Kastritis E, Petraki C, Liapis K, Adamidis K, Apostolou T, Christodoulidou C, Nikolopoulou N, Terpos E, Nakopoulou L, Dimopoulos MA Tags: Clin Nephrol Source Type: research