Current Pharmaceutical Treatments and Alternative Therapies of Parkinson's Diseases.

Current Pharmaceutical Treatments and Alternative Therapies of Parkinson's Diseases. Curr Neuropharmacol. 2015 Nov 20; Authors: Dong J, Zhang Q, Le W Abstract Over the decades, pharmaceutical treatments, particularly dopaminergic (DAergic) drugs have been considered as the main therapy against motor symptoms of Parkinson's disease (PD). It is proposed that DAergic drugs in combination with other medications, such as monoamine oxidase type B inhibitors, catechol-O-methyl transferase inhibitors, anticholinergics and other new developed non-DAergic drugs can make a better control of motor symptoms or alleviate levodopa-induced motor complications. Moreover, non-motor symptoms of PD, such as depression, sleep disorders, cognitive impairment and others caused by intrinsic neurodegeneration or drug-induced side effects, raise great attention these days, and those symptoms need to be treated due to their influence on quality of life. Currently, neuroprotective therapies have been investigated extensively in pre-clinical studies, and some of them have been conducted in clinical trials. The initial results are mixed. Furthermore, non-pharmaceutical treatments, including deep brain stimulation (DBS), gene therapy and cell replacement therapy have also been considered as effective alternative therapies of traditional pharmaceutics. This review will provide us updated information regarding the current drugs and non-drugs therapies for the treatm...
Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Neuropharmacol Source Type: research