Recurrent Subepidermal Blistering Dermatosis Heralding Disease Relapse in IgA kappa Multiple Myeloma: Report of a case and a review of the literature

Multiple myeloma is a malignancy of the plasma cell usually associated with a monoclonal gammopathy, most commonly IgG and IgA.1 While the classic symptoms of multiple myeloma are related to hypercalcemia, renal failure, anemia, and bone disease,1,2 multiple myeloma may also be associated with cutaneous findings, including direct infiltration of malignant cells into the skin presenting as cutaneous plasmacytoma,3 deposition of paraproteins leading to nasal and facial spicules,4 leukocytoclastic vasculitis,5 cryoglobulinemia, amyloidosis, xanthomas,6 hemangiomas, hyperpigmentation and hypertrichosis as seen in POEMS syndrome,7 and rare case reports of paraneoplastic blistering disease.

Source: Clinical Lymphoma, Myeloma and Leukemia - November 20, 2015 Category: Hematology Authors: Hayley W. Leatham, Roberto Novoa, Michaela Liedtke, Bernice Y. Kwong Tags: Case Report Source Type: research