High-Resolution Genomic Profiling of Disseminated Tumor Cells in Prostate Cancer
Circulating and disseminated tumor cells are of great interest because they provide a minimally invasive window for assessing aspects of cancer biology, including tumor heterogeneity, a means to discover biomarkers of disease behavior, and a way to identify and prioritize therapeutic targets in the emerging era of precision oncology. However, the rarity of circulating and disseminated tumor cells poses a substantial challenge to the consistent success in analyzing their molecular features, including genomic aberrations.
Source: Journal of Molecular Diagnostics - Category: Pathology Authors: Yu Wu, Jamie R. Schoenborn, Colm Morrissey, Jing Xia, Sandy Larson, Lisha G. Brown, Xiaoyu Qu, Paul H. Lange, Peter S. Nelson, Robert L. Vessella, Min Fang Source Type: research