The role of calbindin-D28k on renal calcium and magnesium handling during treatment with loop or thiazide diuretics.

In conclusion, CBD-28k plays an important role on gene expression of DCT Ca, but not Mg, transport molecules which may be related to its being Ca, but not Mg, intracellular sensor. The lack of upregulation of DCT Ca transport molecules by thiazides in the KO mice indicates that the DCT Ca transport system is critical for Ca conservation by thiazides. PMID: 26582761 [PubMed - as supplied by publisher]
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research