Down-regulation of osteopontin mediates a novel mechanism underlying the cytostatic activity of TGF-β

Conclusions Our results indicate that the OPN gene is a direct target of Smad-mediated TGF-β signaling, implying that OPN expression inhibition serves as a novel mechanism underlying the cytostatic activity of TGF-β.
Source: Cellular Oncology - Category: Cancer & Oncology Source Type: research