Down-regulation of osteopontin mediates a novel mechanism underlying the cytostatic activity of TGF-β
Conclusions
Our results indicate that the OPN gene is a direct target of Smad-mediated TGF-β signaling, implying that OPN expression inhibition serves as a novel mechanism underlying the cytostatic activity of TGF-β.
Source: Cellular Oncology - Category: Cancer & Oncology Source Type: research
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