Cytomegalovirus Retinitis in Three Pediatric Cases with Acute Lymphoblastic Leukemia: Case Series and Review of the Literature.

Cytomegalovirus Retinitis in Three Pediatric Cases with Acute Lymphoblastic Leukemia: Case Series and Review of the Literature.
Jpn J Infect Dis. 2015 Nov 13;
Authors: Öcal Demir S, Çeliker H, Karaaslan A, Kepenekli Kadayifci E, Akkoç G, Atici S, Yakut N, Şenay E, Kazokoğlu H, Koç A, Bakir M, Soysal A
Abstract
Cytomegalovirus (CMV) retinitis is typically diagnosed in acquired immunodeficiency syndrome (AIDS) patients and allogeneic hematopoietic cell transplant recipients. However, it may develop in patients with acute lymphoblastic leukemia (ALL) not receiving hematopoietic cell transplantation. In order to increase awareness of CMV retinitis in this group herein, we describe three cases aged 3,9,12 years with ALL who developed CMV retinitis. The diagnosis of CMV retinitis was made on the basis of ophthalmological findings suggesting typical retinal lesions. In two cases, CMV DNAemia was present, while in one case CMV DNA was only detected in the vitreous fluid using the polymerase chain reaction technique. All cases were treated with intravenous ganciclovir for two or three weeks as induction therapy, followed by oral valganciclovir prophylaxis. Initially, active retinitis lesions resolved in all cases; however, in one of them CMV retinitis relapsed three times during follow-up. In this case by using foscarnet treatment satisfactory responses were achieved and the progression of CMV retinitis lesions stopped and regressed, ev...

Source: Japanese Journal of Infectious Diseases - November 13, 2015 Category: Infectious Diseases Authors: Öcal Demir S, Çeliker H, Karaaslan A, Kepenekli Kadayifci E, Akkoç G, Atici S, Yakut N, Şenay E, Kazokoğlu H, Koç A, Bakir M, Soysal A Tags: Jpn J Infect Dis Source Type: research