Pathogenic description of Streptococcus pyogenes among invasive and non-invasive diseases in Aichi, Japan.

Pathogenic description of Streptococcus pyogenes among invasive and non-invasive diseases in Aichi, Japan. Jpn J Infect Dis. 2015 Nov 13; Authors: Matsumoto M, Yamada K, Suzuki M, Adachi H, Kobayashi S, Yamashita T, Minagawa H, Tatsuno I, Hasegawa T Abstract We determined the presence of hypervirulent S. pyogenes in 27 and 420 isolates from patients with invasive and non-invasive diseases, respectively, in Aichi Prefecture, Japan between 2003 and 2012 to determine why the prevalence of streptococcal toxic shock syndrome (STSS) suddenly increased in this location during 2011. The hypervirulent strain is defined by the emm1 genotype, a mutation of covR/S genes that regulates many other genes, encoding virulence determinants and results in the absence of proteinase, streptococcal exotoxin B (SpeB) and the production of virulence factors such as superantigen, streptococcal exotoxin A (SpeA); nuclease, streptococcal DNase (Sda1); cytotoxin, NAD-glycohydrolase (NADase) and hemolysin, streptolysin O (SLO). We found one strains from invasive and one from non-invasive isolates with similar traits to those of hypervirulent strains except for the absence of the sda1 gene. We also found one non-emm1 strain with phenotypical and genetic traits identical to those of the emm1 hypervirulent strain except for the emm1 genotype, from the non-invasive diseases in 2011. These findings suggested that hypervirulent and hypervirulent-like strains from inva...
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research