Ca(2+) dependent but PKC independent signalling mediates UTP induced contraction of rat mesenteric arteries.

In conclusion, both UTP induced contraction of mesenteric artery and the inhibition of Kv and KATP currents of mesenteric artery smooth muscle cells by UTP are relatively independent of PKC activation; furthermore, the inhibition of both Kv and KATP currents requires intracellular Ca(2+).
PMID: 26447104 [PubMed - in process]

Source: Journal of Smooth Muscle Research - November 19, 2015 Category: Research Tags: J Smooth Muscle Res Source Type: research