Ryanodine receptor cluster fragmentation and redistribution in persistent atrial fibrillation enhance calcium release

Conclusion
In persistent AF, ultrastructural reorganization of RyR clusters within CRUs is associated with overactive Ca2+ release, increasing the likelihood of propagating Ca2+ release.

Source: Cardiovascular Research - November 17, 2015 Category: Cardiology Authors: Macquaide, N., Tuan, H.-T. M., Hotta, J.-i., Sempels, W., Lenaerts, I., Holemans, P., Hofkens, J., Jafri, M. S., Willems, R., Sipido, K. R. Tags: Ion Channels and Arrhythmias Source Type: research