Dysregulation of interferon regulatory factors impairs the expression of immunostimulatory molecules in hepatitis C virus genotype 1-infected hepatocytes

Conclusions
HCV genotype 1 infection downregulates IRF2 in hepatocytes attenuating hepatocellular expression of IL-7 and IL-15Rα. Our data reveal a new mechanism by which HCV abrogates specific T-cell responses and point to a novel therapeutic approach to stimulate anti-HCV immunity.

Source: Gut - February 27, 2014 Category: Gastroenterology Authors: Larrea, E., Riezu-Boj, J.-I., Aldabe, R., Guembe, L., Echeverria, I., Balasiddaiah, A., Gastaminza, P., Civeira, M. P., Sarobe, P., Prieto, J. Tags: Hepatitis C Hepatology Source Type: research