Canonical Wnt signals combined with suppressed TGF{beta}/BMP pathways promote renewal of the native human colonic epithelium

Conclusions Steady-state tissue renewal in the native human colonic epithelium is dependent on canonical Wnt signals combined with suppressed TGFβ/BMP pathways. Stem/progenitor cell proliferation is uncoupled from crypt cell migration and shedding, and is required to constantly replenish the crypt cell population.

http://gut.bmj.com/cgi/content/short/63/4/610?rss=1

Source: Gut - February 27, 2014 Category: Gastroenterology Authors: Reynolds, A., Wharton, N., Parris, A., Mitchell, E., Sobolewski, A., Kam, C., Bigwood, L., El Hadi, A., Munsterberg, A., Lewis, M., Speakman, C., Stebbings, W., Wharton, R., Sargen, K., Tighe, R., Jamieson, C., Hernon, J., Kapur, S., Oue, N., Yasui, W., W Tags: Open access Colon Source Type: research