Collagen degradation and neutrophilic infiltration: a vicious circle in inflammatory bowel disease

Conclusions
The proteolytic cascade that generates PGP from collagen, as well as the tripeptide itself, is present in the intestine of patients with IBD and mice with DSS-induced colitis. PGP neutralisation in DSS-treated mice showed the importance of PGP-guided neutrophilic infiltration in the intestine and indicates a vicious circle in neutrophilic inflammation in IBD.

Source: Gut - February 27, 2014 Category: Gastroenterology Authors: Koelink, P. J., Overbeek, S. A., Braber, S., Morgan, M. E., Henricks, P. A. J., Roda, M. A., Verspaget, H. W., Wolfkamp, S. C., te Velde, A. A., Jones, C. W., Jackson, P. L., Blalock, J. E., Sparidans, R. W., Kruijtzer, J. A. W., Garssen, J., Folkerts, G. Tags: Open access Inflammatory bowel disease Source Type: research