Merck Announces Presentation of Phase 3 Results of Investigational Elbasvir/Grazoprevir in People with Chronic Hepatitis C Genotypes 1, 4 or 6 Infection Who Inject Drugs and Are on Opioid Agonist Therapy

Dateline City: KENILWORTH, N.J. Results from C-EDGE CO-STAR Presented at The Liver Meeting® Show High Sustained Virologic Response After 12 Weeks of Treatment KENILWORTH, N.J.--(BUSINESS WIRE)--Merck (NYSE:MRK), known as MSD outside the United States and Canada, today announced the presentation of results from the company’s Phase 3 C-EDGE CO-STAR clinical trial evaluating the efficacy and safety of the investigational once-daily tablet elbasvir/grazoprevir1 (50mg/100mg) in patients with chronic hepatitis C virus (HCV) genotypes (GT) 1, 4 or 6 infection who inject drugs and are receiving opioid agonist therapy (OAT). Language: English Contact: MerckMedia Contacts:Doris Li, 908-246-5701Sarra Herzog, 201-669-6570orInvestor Contacts:Teri Loxam, 908-740-1986Justin Holko, 908-740-1879 Ticker Slug: Ticker: MRK Exchange: NYSE read more
Source: Merck.com - Research and Development News - Category: Pharmaceuticals Tags: Research and Development News Corporate News Latest News #Merck #MRK $MRK Hep C Hepatitis C MSD NYSE:MRK Source Type: news

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Condition:   Hepatitis C Interventions:   Behavioral: Opt-Out;   Behavioral: Letter;   Behavioral: Behavioral Economic Messaging;   Behavioral: Usual Care Messaging Sponsor:   University of Pennsylvania Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Study focused on chemo for stomach cancer Related items fromOnMedica Cancer patients using complementary meds die sooner Cancer strategies failed to improve one-year survival FOB associated with rise in all-cause mortality Antivirals cut liver cancer risk after hepatitis C NICE recommends Herceptin for gastric cancer
Source: OnMedica Latest News - Category: UK Health Source Type: news
International Journal of Rheumatic Diseases, EarlyView.
Source: APLAR Journal of Rheumatology - Category: Rheumatology Authors: Source Type: research
Frank Surup 4-Hydroxypleurogrisein, a congener of the anticancer-lead compound pleurotin, as well as six further derivatives were isolated from the basidiomycete Hohenbuehelia grisea, strain MFLUCC 12-0451. The structures were elucidated utilizing high resolution electron spray ionization mass spectrometry (HRESIMS) and 1D and 2D nuclear magnetic resonance (NMR) spectral data and evaluated for their biological activities; for leucopleurotin, we provide Xray data. While most congeners showed moderate antimicrobial and cytotoxic activity, 4-hydroxypleurogrisein emerged as an inhibitor of hepatitis C virus infectivity in ...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Publication date: November 2018Source: American Journal of Preventive Medicine, Volume 55, Issue 5Author(s):
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Publication date: November 2018Source: American Journal of Preventive Medicine, Volume 55, Issue 5Author(s): Sarah F. Schillie, Lauren Canary, Alaya Koneru, Noele P. Nelson, Wade Tanico, Harvey W. Kaufman, Susan Hariri, Claudia J. VellozziIntroductionPerinatal transmission is an increasingly important mode of hepatitis C virus transmission. The authors characterized U.S. births among hepatitis C virus–infected women and evaluated trends in hepatitis C virus testing and positivity in women of childbearing age, pregnant women, and children aged less than 5years.MethodsIn 2017, National Center for Health Statistics birt...
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
ConclusionsIncluding and engaging communities at risk for HIV and hepatitis C virus infection in prevention research is a promising strategy to overcome existing barriers of stigma and discrimination. Integration of HIV and hepatitis C virus testing in universal health screening efforts utilizing a Community Health Advisors model encourages unbiased communication with a focus on overall community health. Community health advisors are recognized as important agents in this effort.Supplement informationThis article is part of a supplement entitled African American Men's Health: Research, Practice, and Policy Implications, wh...
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Alimentary Pharmacology&Therapeutics, EarlyView.
Source: Alimentary Pharmacology and Therapeutics - Category: Drugs & Pharmacology Authors: Source Type: research
AbstractPurpose of reviewAn increasing number of specialists and non-specialists are developing clinical programs to treat and cure hepatitis C virus (HCV). The goal of this paper is to evaluate and describe optimal strategies to improve outcomes related to HCV care delivery.Recent findingsScreening and diagnosis of HCV should be guided by established recommendations. Given the recognized disparity in HCV diagnosis and linkage to care, a multi-modal approach involving care coordination and technology resources should be used to improve patient engagement. Access to HCV treatment may be optimized through systematic document...
Source: Current Treatment Options in Infectious Diseases - Category: Infectious Diseases Source Type: research
ConclusionThere might be a global changing figure regarding etiologies of HCC in Latin America. This epidemiological change on the incidence of HCC in the world, although it has been reported, should still be confirmed in prospective studies.
Source: Clinics and Research in Hepatology and Gastroenterology - Category: Gastroenterology Source Type: research
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