Analysis of the relationship between PM2.5 and lung cancer based on protein-protein interactions.

This study constitutes the analysis of the association between PM2.5 and lung cancer. Genes related to small/nonsmall cell lung cancer were evaluated by assigning scores to measure the impact caused by PM2.5. Analyses of small/nonsmall cell lung cancer genes with high scores revealed that it is theoretically possible that PM2.5 is an etiologic factor for lung cancer. Our results provided new insights of the relationship between lung cancers and air pollution. PMID: 26552437 [PubMed - as supplied by publisher]
Source: Combinatorial Chemistry and High Throughput Screening - Category: Chemistry Authors: Tags: Comb Chem High Throughput Screen Source Type: research

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Source: Journal of Toxicology and Environmental Health Part A - Category: Environmental Health Authors: Source Type: research
This study confirmed that quantitative health risk assessments and participatory approaches are powerful tools to support public decisions and build constructive communication between exposed people, experts, and policy-makers.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Officials in Asbestos, Quebec, have been struggling for years to develop a new identity for the small Canadian mining town. Changing its name might do the trick. Mayor Hugues Grimard announced recently that his town in southeastern Quebec is looking for a name change in 2020, believing it could spark a much-needed economic recovery. The natural link between the town’s name and the toxic mineral — once so compelling — has become a roadblock to any future development. Exposure to asbestos can lead to deadly diseases, including mesothelioma cancer. “There is really a negative perception around asbestos...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Although mesothelioma is the consequence of a protracted immune response to asbestos fibers and characterized by a clear immune infiltrate, novel immunotherapy approaches show less convincing results as compared to those seen in melanoma and non-small cell lung cancer. The immune suppressive microenvironment in mesothelioma is likely contributing to this therapy resistance. Therefore, it is important to explore the characteristics of the tumor microenvironment for explanations for this recalcitrant behavior. This review describes the stromal, cytokine, metabolic, and cellular milieu of mesothelioma, and attempts to make co...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Thoracic surgeon Dr. Marcelo DaSilva came to Orlando, Florida, with a lofty goal. He wants to make Central Florida a destination for patients diagnosed with malignant pleural mesothelioma. DaSilva also has the tools to make that goal a reality, building a mesothelioma specialty program at AdventHealth Orlando. “We want to make this a nationally — and internationally — recognized program,” DaSilva told The Mesothelioma Center at “People who come to Orlando will not only see Disney World, but they will see excellence in health care. We can do that here.” DaSilva was named chi...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Asbestos may have been banned in the United Kingdom 20 years ago, but the deadly carcinogen continues to be the leading cause of occupational death, leading to 5,500 deaths in the U.K. last year. According to a new report by ResPublica, an estimated six million tons of the deadly carcinogen remain inside 1.5 million buildings in the U.K., including schools and hospitals — many of which were built prior to the 1999 ban. Exposure to asbestos is directly connected to multiple diseases, including mesothelioma, lung cancer and asbestosis. Jump to the full infographic: Asbestos Risk in UK Hospital...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Campaigners call for urgent action to hit pollution reduction targets Related items fromOnMedica UK asbestos regulations slammed High pollution days send hundreds to hospital Hitting clean air targets would prevent 10,000 UK child asthma cases Traffic pollution linked to 'millions' of childhood asthma cases Cars should be banned from around schools
Source: OnMedica Latest News - Category: UK Health Source Type: news
(Impact Journals LLC) Cryopreserved cell-free PE fluid from 101 NSCLC patients, 8 mesothelioma and 13 with benign PE was assayed for a panel of 40 cytokines/chemokines using the Luminex system. Comparing NSCLC PE and published plasma levels of CAR-T recipients, both were dominated by sIL-6R and IL-6 but NSCLC PE had more VEGF, FGF2 and TNF, and less IL-2, IL-4, IL-13, IL-15, MIP1 and IFN.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Conditions:   Non Small Cell Lung Cancer;   Non-squamous Non-small-cell Lung Cancer;   Urothelial Carcinoma;   Malignant Mesothelioma Interventions:   Drug: Cabozantinib;   Drug: Pemetrexed Sponsor:   Augusta University Not yet recruiting
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