Cleveland Clinic to offer uterus transplants in clinical trial

Stephen FellerCLEVELAND, Nov. 13 (UPI) -- Doctors have started screening women for the first uterus transplants done in the United States in the hope of helping women with uterine factor infertility.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news

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This study summarizes ovarian tissue cryopreservation and transplantation indications, procedures, their efficacy and main results and proposes different strategies to improve this strategy. Although the main focus of this study is on ovarian tissue cryopreservation and transplantation as a strategy to restore fertility, we believe that it is also important to discuss other applications for this approach.
Source: Best Practice and Research Clinical Endocrinology and Metabolism - Category: Endocrinology Source Type: research
Purpose of review The current review gives an updated synopsis of all cases of uterus transplantation (UTx) that has been published and technical details about surgery. The live births that so far have been reported are described regarding pregnancy and outcome. In addition, the review highlights some specific areas of live donor UTx, deceased donor UTx and UTx in general that need further research for clarification/optimization. It is predicted that the clinical field of UTx will expand rapidly and recommendations for a scientific development of the UTx field are presented. Recent findings The first successful UTx wa...
Source: Current Opinion in Organ Transplantation - Category: Surgery Tags: COMPOSITE TISSUE TRANSPLANTATION: Edited by Gerald Brandacher Source Type: research
Uterus transplantation (UTx) is an option for women with uterine factor infertility to achieve motherhood. Since the first live birth in 2014 in Sweden, the demand for this novel therapy has been expanding around the world. While living donors have largely met the current demand, it is projected that donor availability will rapidly become limited as this experimental therapy becomes standard of care. There is thus a great need to quantify the pool of potential deceased uterus donors. This knowledge is necessary not only to guide centers starting uterus transplant programs but ultimately to inform donor and recipient select...
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Oral session Source Type: research
The decidua is a transient uterine tissue shared by mammals with hemochorial placenta and is essential for pregnancy. Hoxa11 knockout (KO) mice are infertile having endometrial stromal cell defects resulting in lack of decidualization and implantation failure. Since bone marrow (BM)-derived cells (BMDC) were shown to differentiate into non-hematopoietic endometrial cells, we hypothesized that bone marrow transplantation from wild-type (WT) mice may rescue uterine defects in Hoxa11 KO mice.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Oral session Source Type: research
Uterus transplantation (UTx) is an evolving curative therapy for uterine factor infertility (UFI). While live births have been achieved at a handful of centers around the world, estimating the need for UTx is essential prior to expansion of this innovative therapy. Reports from uterine transplant programs at Baylor University Medical Center at Dallas and Cleveland Clinic Foundation suggest great interest in UTx from the community. The purpose of this study was to quantify and characterize candidacy and interest in UTx at a high-volume transplant center in the Northeast.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Poster session Source Type: research
ConclusionThe majority of respondents in a sample of US residents support UTx, find it ethical, and believe that it is an acceptable alternative to a gestational carrier although support varies. These findings suggest that the US public is in favor of uterine transplantation as a treatment for uterine factor infertility.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
ConclusionJust under half of the reproductive endocrinologists and minimally invasive surgeons surveyed find uterine transplantation to be an ethical option for patients with AUFI. Important concerns remain regarding the risk to donors, recipients, and resulting infants, all contributing to only a minority currently recommending it as a therapeutic option.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Abstract Spermatogonial stem cells (SSCs) provide the foundation of spermatogenesis. However, because of their small number and slow self-renewal, transfection of SSCs has met with limited success. Although several viral vectors can infect SSCs, genome integration and an inability to maintain long-term gene expression have hampered studies on SSCs. Here we report successful SSC infection by Sendai virus (SV), an RNA virus in the Paramyxoviridae. The SV efficiently transduced germline stem (GS) cells, cultured spermatogonia with enriched SSC activity, and maintained gene expression for at least 5 months. It also in...
Source: Biology of Reproduction - Category: Reproduction Medicine Authors: Tags: Biol Reprod Source Type: research
uml;m M Abstract PURPOSE OF REVIEW: The current review gives an updated synopsis of all cases of uterus transplantation (UTx) that has been published and technical details about surgery. The live births that so far have been reported are described regarding pregnancy and outcome. In addition, the review highlights some specific areas of live donor UTx, deceased donor UTx and UTx in general that need further research for clarification/optimization. It is predicted that the clinical field of UTx will expand rapidly and recommendations for a scientific development of the UTx field are presented. RECENT FINDINGS:...
Source: Current Opinion in Organ Transplantation - Category: Transplant Surgery Authors: Tags: Curr Opin Organ Transplant Source Type: research
This article is protected by copyright. All rights reserved. PMID: 30125449 [PubMed - as supplied by publisher]
Source: BJOG : An International Journal of Obstetrics and Gynaecology - Category: OBGYN Authors: Tags: BJOG Source Type: research
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