Cleveland Clinic to offer uterus transplants in clinical trial
Stephen FellerCLEVELAND, Nov. 13 (UPI) -- Doctors have started screening women for the first uterus transplants done in the United States in the hope of helping women with uterine factor infertility.
Dr. Giuliano Testa, a transplant surgeon at Baylor University Medical Center at Dallas who led the medical team that performed the first successful uterus transplants in the United States, said Tuesday that he hopes “what we are doing is going to shed light on infertility for women.” “I personally never knew it was such a widespread issue,” Testa said at the TIME 100 Gala on Tuesday. “We should be thinking about it not just as a birth, but a wellbeing issue.” Testa attended the TIME 100 Gala after being named by TIME magazine as one of the most influential people in the world for his rol...
Authors: Dolmans MM, Masciangelo R Abstract Improvements in cancer treatments have increased the chances of survival of young cancer patients, but have given rise to other issues, like premature ovarian insufficiency and infertility. Preservation and subsequent restoration of ovarian function in these patients is now possible thanks to ovarian tissue cryopreservation and transplantation. However, safety concerns about the possible presence of cancerous cells in the tissue to be cryopreserved must be addressed. Indeed, reimplantation of malignant cell-contaminated ovarian tissue could potentially lead to recurrence ...
Conditions: Primary Ovarian Insufficiency; Female Infertility Intervention: Procedure: Ovarian tissue transplant Sponsor: University of Pittsburgh Not yet recruiting
Transplantation of the uterus is required in cases of absolute uterine factor infertility (AUFI), which are caused either because of uterus deficiency (congenital or after a hysterectomy) or existence of non-functional uterus.
Uterus transplantation (UTx) has been successfully introduced as a treatment option for women with absolute uterine factor infertility (AUFI). AUFI representing approximately 3% to 5% of the female general population is linked to either congenital uterine agenesis (Mayer-Rokitansky-Küster-Hauser syndrome), major congenital uterine malformation (hypoplastic uterus, fraction of bicornuate/unicornuate uterus), a surgically absent uterus, or an acquired condition (intrauterine adhesions, leiomyoma) linked to uterine malfunction that causes implantation failure or defect placentation. The world’s first clinical uteru...
This study presents a summary of the investigations that indicate the key role of stem cell therapy in regeneration and renovation of defective parts.
Although cancer remains a critical health concern, significant medical advances in cancer detection and treatment have improved survival rates for patients. In children receiving total body radiation (TBI), bone-marrow transplant (BMT), or cyclophosphamide equivalent dose (CED) of>4,000mg/m2, the risk of infertility is significant. The National Physicians Cooperative (NPC) has published site-specific articles compiling data regarding use of cryopreserved tissue, return of endocrine function, and pregnancy outcomes, however no comprehensive review has been conducted.
Reduced intensity conditioning (RIC) is increasingly used for hematopoietic stem cell transplantation (HCT). Risk of infertility and primary gonadal insufficiency secondary to standard myeloablative (MAC) HCT is high, but little is known of these complications following use of RIC HCT.