Uterus Transplants May Soon Help Some Infertile Women in the U.S. Become Pregnant

Surgeons at the Cleveland Clinic are set to become the first in the United States to transplant a uterus.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Uterus Transplants Infertility Pregnancy and Childbirth Cleveland Clinic Source Type: news

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To regenerate functional endometrium tissue using “cell sheet” techniques as a regenerative medicine approach to address endometrial disorders causing female factor infertility.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Original article Source Type: research
Abstract Severe uterine damage and infection lead to intrauterine adhesions, which result in hypomenorrhea, amenorrhea and infertility. Cell sheet engineering has shown great promise in clinical applications. Adipose-derived stem cells (ADSCs) are emerging as an alternative source of stem cells for cell-based therapies. In the present study, we investigated the feasibility of applying ADSCs as seed cells to form scaffold-free cell sheet. Data showed that ADSC sheets expressed higher levels of FGF, Col I, TGFβ and VEGF than ADSCs in suspension, while increased expression of this gene set was associated with st...
Source: Biology of Reproduction - Category: Reproduction Medicine Authors: Tags: Biol Reprod Source Type: research
Purpose of review The purpose of this review is to analyze what is known to date about the relation between telomeres and male fertility, and if it is possible for telomeres, or elements related to them, to be used as new prognostic biomarkers in fertility treatment. Recent findings Cells in germ series, including spermatozoids, have longer telomeres (10–20 kb), and do not seem to undergo the shortening that takes place in somatic cells with age as they present telomerase activity. Longer telomere length found in the sperm of older fathers, influences their offspring possessing cells with longer telomere length....
Source: Current Opinion in Obstetrics and Gynecology - Category: OBGYN Tags: FERTILITY, IVF AND REPRODUCTIVE GENETICS: Edited by Emre Seli and Juan A. García-Velasco Source Type: research
Dr. Giuliano Testa, a transplant surgeon at Baylor University Medical Center at Dallas who led the medical team that performed the first successful uterus transplants in the United States, said Tuesday that he hopes “what we are doing is going to shed light on infertility for women.” “I personally never knew it was such a widespread issue,” Testa said at the TIME 100 Gala on Tuesday. “We should be thinking about it not just as a birth, but a wellbeing issue.” Testa attended the TIME 100 Gala after being named by TIME magazine as one of the most influential people in the world for his rol...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized onetime T1002018 Source Type: news
Although cancer remains a critical health concern, significant medical advances in cancer detection and treatment have improved survival rates for patients. In children receiving total body radiation (TBI), bone-marrow transplant (BMT), or cyclophosphamide equivalent dose (CED) of>4,000mg/m2, the risk of infertility is significant. The National Physicians Cooperative (NPC) has published site-specific articles compiling data regarding use of cryopreserved tissue, return of endocrine function, and pregnancy outcomes, however no comprehensive review has been conducted.
Source: Journal of Pediatric and Adolescent Gynecology - Category: OBGYN Authors: Source Type: research
This study presents a summary of the investigations that indicate the key role of stem cell therapy in regeneration and renovation of defective parts.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Although cancer remains a critical health concern, significant medical advances in cancer detection and treatment have improved survival rates for patients. In children receiving total body radiation (TBI), bone-marrow transplant (BMT), or cyclophosphamide equivalent dose (CED) of>4,000mg/m2, the risk of infertility is significant. The National Physicians Cooperative (NPC) has published site-specific articles compiling data regarding use of cryopreserved tissue, return of endocrine function, and pregnancy outcomes, however no comprehensive review has been conducted.
Source: Journal of Pediatric and Adolescent Gynecology - Category: OBGYN Authors: Source Type: research
This study presents a summary of the investigations that indicate the key role of stem cell therapy in regeneration and renovation of defective parts. PMID: 29571018 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
Hormonal changes, in either men or women experiencing chronic kidney disease (CKD), cause a decreased libido, erectile dysfunction, dysmenorrhea and ovarian dysfunction, all of which may contribute to infertility. Patients could rapidly restore endocrines and sexual function after a successful renal transplantation (RTx), which may assist in achieving a successful pregnancy. However, the fetus will be exposed to the immunosuppressive agents passed on from the female recipients, which may be another potential factor leading to a poor fetal outcome.
Source: Transplantation Proceedings - Category: Transplant Surgery Authors: Source Type: research
Kidney transplantation (KTx) is the treatment of choice in patients with end-stage renal failure. Among various medical issues in female graft recipients, the need for maternity can become an overriding one. Gonadal dysfunction usually resolves within 6 months after transplantation. However, the prevalence of infertility is similar to this in the general population.
Source: Transplantation Proceedings - Category: Transplant Surgery Authors: Source Type: research
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