The miR-17-92 cluster counteracts quiescence and chemoresistance in a distinct subpopulation of pancreatic cancer stem cells

Conclusions
Our findings therefore identify the miR-17-92 cluster as a functionally determining family of miRNAs in CSCs, and highlight the putative potential of developing modulators of this cluster to overcome drug resistance in pancreatic CSCs.

Source: Gut - November 8, 2015 Category: Gastroenterology Authors: Cioffi, M., Trabulo, S. M., Sanchez-Ripoll, Y., Miranda-Lorenzo, I., Lonardo, E., Dorado, J., Reis Vieira, C., Ramirez, J. C., Hidalgo, M., Aicher, A., Hahn, S., Sainz, B., Heeschen, C. Tags: Pancreas and biliary tract, Open access, Pancreatic cancer Source Type: research