New Holding Company Prepares Arkansas Mutual for Expansion
A.M. Best Co.’s succinct announcement that Arkansas Mutual Insurance Co. had achieved an A rating was the culmination of two years of work by the Arkansas-only medical malpractice carrier to get ahead of a changing market. “This now solidifies Arkansas Mutual for decades to come,” President Corey Little said last week. “It’s not pride: It’s what happens in every state with a home-state mutual.” Arkansas Mutual was formed eight years ago to create in-state competition for the out-of-state carriers that swept in when St. Paul Cos. abandoned the med-mal market completely in 2001. After starting from scratch, Arkansas Mutual now insures about 800 physicians in the state, Little said last week. 2015 revenue will be about $4 million, he said. But during the company’s short life, the doctoring business has changed dramatically. Doctors in Arkansas as elsewhere have been leaving individual practice in droves and becoming employees of hospital-owned clinics. “When we first went to see St. Bernards, they had four hospitalists on staff,” Little said of the Jonesboro health system. “Now they have 160 employed physicians.” Similarly, CARTI — Central Arkansas Radiation Therapy Institute Inc. — did not directly employ physicians until it acquired two physician groups, Little Rock Hematology &Oncology in December 2011 and Hematology Oncology Services of Arkansas in January 2013. Hospital bylaws typically ...
Carotid artery stenting (CAS) is a valuable solution for the treatment of carotid artery stenosis in a population of patients at high risk for carotid endarterectomy (CEA). This high-risk population includes patients with recurrent stenosis after CEA, high/low lesion, contralateral laryngeal nerve palsy, previous radical neck surgery, cervical radiation therapy, and tracheostomy. In the European Society for Vascular Surgery guidelines, however, the authors were concerned about the death and stroke rates of CAS in “real-world” practice.
Whole-breast radiation therapy can significantly lower the risk of recurrent...Read more on AuntMinnie.comRelated Reading: Can dedicated breast PET identify suspicious lesions? Women still need breast imaging after mastectomy Is radiation therapy warranted for DCIS postlumpectomy? Microbubbles improve breast cancer radiation therapy ASTRO: Short radiation course safe for breast cancer
The objective of this study was to investigate canine gliomas for the IDH1 R132H point mutation using immunohistochemistry. Thirty-one formalin-fixed and paraffin wax-embedded canine gliomas were examined for both IDH1 R132H expression and pan-IDH1 (IDH1 wild-type and point mutated IDH1). Glial tumour specimens were recorded to be either positive or negative for expression. Pan-IDH1 expression was identified in all 31 tumours (100%), while the IDH1 R132H point mutation was identified in none of the tumours (0%). Therefore, the IDH1 R132H point mutation was not identified in this population of canine gliomas and may not be ...
A larger, weekly dose of radiation therapy has side effects that are comparable...Read more on AuntMinnie.comRelated Reading: Can dedicated breast PET identify suspicious lesions? Women still need breast imaging after mastectomy Is radiation therapy warranted for DCIS postlumpectomy? Microbubbles improve breast cancer radiation therapy ASTRO: Short radiation course safe for breast cancer
ConclusionWe minimized near-miss incidents by using limited simulation user origins, converting user origin-to-isocenter shifts to absolute couch parameters, and enforcing restrictive tolerance tables to limit delivery parameter changes, coupled with surface guidance and quality assurance tools. This technique can be applied across institutions, age ranges, and tumor types and with or without surface guidance. This workflow has removed a common treatment setup error and the need for skin marks.
In conclusion, the combination of the two prediction systems may increase the treatment efficacy for patients with MIBC by proposing the optimal NAC regimen. In addition, the positive PS group would have a better prognosis compared with the negative PS group. These results suggest that the two prediction systems may lead to the achievement of 'precision medicine'. PMID: 30333861 [PubMed]
Authors: Okimoto T, Tsubata Y, Hotta T, Hamaguchi M, Nakao M, Hamaguchi SI, Hamada A, Isobe T Abstract The central nervous system is a common site of relapse in patients receiving crizotinib, which is presumed to be associated with the low concentration of crizotinib in the cerebrospinal fluid (CSF). Our patient received surgical treatment for anaplastic lymphoma kinase-positive stage IIA lung adenocarcinoma. His cancer recurred with brain metastases and carcinomatous meningitis. We started whole-brain radiation therapy (WBRT) and subsequently administered crizotinib. The concentration of crizotinib on day 15 in th...
ConclusionsGenerally, superior vena cava syndrome is the result of extrinsic compression of the superior vena cava by tumor. Our patient ’s case represents the development of superior vena cava syndrome after an excellent response of tumor with near-complete tumor response. We suspect chemoradiation therapy as a potential etiology for the precipitation of the superior vena cava syndrome, which is currently not well reported in the medical literature.
It's OK for patients scheduled for radiation therapy to apply topical treatments...Read more on AuntMinnie.comRelated Reading: Midtreatment boost during WBRT reduces skin dermatitis ASTRO: Thermal tomo may predict skin response
Condition: Uveal Melanoma Interventions: Radiation: Stereotactic Body Radiation Therapy; Biological: Ziv-Aflibercept Sponsors: Sidney Kimmel Cancer Center at Thomas Jefferson University; Regeneron Pharmaceuticals Not yet recruiting