Sex differences in protein expression in the mouse brain and their perturbations in a model of Down syndrome

Conclusions The extensive sex differences in control mice in levels of proteins involved in learning/memory illustrate the molecular complexity underlying sex differences in normal neurological processes. The sex-specific abnormalities in the Dp10 suggest the possibility of sex-specific phenotypic features in DS and reinforce the need to use female as well as male mice, in particular in preclinical evaluations of drug responses.
Source: Biology of Sex Differences - Category: Biology Source Type: research