Isosorbide Mononitrate Might Reduce Physical Activity in Heart Failure Patients with Preserved Ejection (FREE)

By Frederick A. Masoudi, MD, MSPH, FACC, FAHA Dr. Masoudi is an associate editor with NEJM Journal Watch Cardiology, from which this story was adapted. See full coverage at the link below.Nitrates may adversely affect activity levels in patients with heart failure and preserved left ventricular ejection fraction, according to a multicenter, …
Source: Physician's First Watch current issue - Category: Primary Care Source Type: news

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Conclusion: Here, we reveal several Nrf2 dose-responsive miRNA loci harboring putative upstream antioxidant response elements (AREs). Intriguingly, Nrf2-mediated miRNA responses were distinctly enriched for post-transcriptional regulation of cardiac-specific mRNAs. Altogether, these data reveal Nrf2 as a potent regulator of cardiac miRNA expression and provide novel candidates for future mechanistic investigation into the relationship between myocardial redox status and pathophysiology.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Mus musculus Source Type: research
Conclusion: Here, we reveal several Nrf2 dose-responsive miRNA loci harboring putative upstream antioxidant response elements (AREs). Intriguingly, Nrf2-mediated miRNA responses were distinctly enriched for post-transcriptional regulation of cardiac-specific mRNAs. Altogether, these data reveal Nrf2 as a potent regulator of cardiac miRNA expression and provide novel candidates for future mechanistic investigation into the relationship between myocardial redox status and pathophysiology.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
In the era of increased left ventricular support device (LVAD) implantation, limited data is available on outcomes in the obese population, with most available data describing elevated BMI with a cutoff of>30 kg/m2. Forest et al examined the ISHLT Mechanically Assisted Circulatory Support (IMACS) registry and found no impact in 2-year mortality in those with higher BMIs, but an increase in all adverse events describing BMI> 40 kg/m2 group. We seek to provide our experience with this population.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (69) Source Type: research
The objectives of this study were to describe survival, characterize rates of adverse events (AEs) and compare survival after an AE in patients age ≥70 vs. age 50-69.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (67) Source Type: research
Amyloid transthyretin (ATTR) cardiac amyloidosis (CA) is an increasingly recognized cause of restrictive cardiomyopathy and associated heart failure with preserved ejection fraction (HFpEF). Despite improved diagnostic techniques to identify this condition, many patients experience delayed diagnosis. Interpretation of routine cardiac biomarkers (i.e. troponins and brain natriuretic peptide (BNP)) and echocardiography in ATTR-CA is limited, particularly in relation to pyrophosphate (PYP) scintigraphy.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (64) Source Type: research
Patients with heart failure (HF) requiring advanced therapies (AT) or palliative inotropes have been well described in the literature, but less is known regarding their earlier clinical course. Patients started on inotropes may be appropriate candidates for AT, yet do not always receive timely evaluations. Given the high mortality associated with end stage HF, we investigated the clinical characteristics and outcomes of HF patients after initiation of inotrope therapy.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (63) Source Type: research
Exercise tolerance has important prognostic value in patients with heart failure and reduced ejection fraction (HFrEF). The relationship between right ventricular function and its coupling to pulmonary circulation (RV-PA) and cardiopulmonary exercise tests (CPET) is not fully understood. We aimed to evaluate the value of RV echocardiographic parameters, including RV-PA, to predict exercise tolerance in HFrEF patients.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (62) Source Type: research
We examined the association between MAGGIC predicted prognosis and actual outcomes, in order to assess predictive performance of the score and determine a threshold for identifying patients at risk.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (61) Source Type: research
We hypothesized that a novel invasive hemodynamic measure reflecting cardiac contractility and filling pressure would predict long-term prognosis.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (60) Source Type: research
Heart transplantation (HT) and mechanical circulatory support (MCS) has improved heart failure (HF) patient (PT) outcomes; it has also led to increased caregiver (CG) responsibility pre and post-surgery. We assessed whether PT and CG factors were related to baseline CG perceived burden in 3 groups of CGs of HF PTs (60-80 years): (1) PT supported with MCS as a bridge to HT (HT BTT), (2) PT awaiting HT without MCS (HT non BTT), and (3) PT prior to MCS for destination therapy (DT MCS).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (59) Source Type: research
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