Inflammatory regulation of steroid sulfatase: A novel mechanism to control estrogen homeostasis and inflammation in chronic liver disease

Abnormal estrogen metabolism in liver disease has been long recognized in the clinic. Concomitants of liver diseases are clinical signs and symptoms like palmar erythema, spider nevus, gynecomastia, and infertility due to disturbed homeostasis of steroid hormones, especially the estrogens. Studies have reported increased estrogen levels and signs of endocrine disturbance in patients with chronic liver diseases [1]. The hormone levels are positively correlated to the severity of the liver disease [2], whereas treating patients towards improved liver function resulted in regression of endocrine disturbance [3].
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Research Article Source Type: research