Clinical outcomes of surgery after induction treatment in patients with pathologically proven N2-positive stage III non-small cell lung cancer.

CONCLUSIONS: These data suggest that neoadjuvant therapy was feasible, and helpful for tumor and pathologic nodal downstaging with promising rates of survival in patients with stage IIIA-N2 NSCLC. After induction therapy, patients with potentially radical lobectomy were more likely to benefit from operation. Pathological nodal downstaging of pN2 to pN0-1, rather than clinical response was predictive of a favorable outcome, and was correlated with a better chance of survival. PMID: 26543609 [PubMed]

http://www.ncbi.nlm.nih.gov/pubmed/26543609?dopt=Abstract

Source: Journal of Thoracic Disease - November 8, 2015 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research