Geodon Is Less Effective for the Obese, Hyperglycemic
Geodon (ziprasidone), an atypical antipsychotic often prescribed for patients with bipolar disorder, is far less likely to be effective in patients with a BMI of 28.8 or higher and/or a ...Read Full Post
ConclusionsWe conclude that RELN signaling is modulated by diet, that RELN is involved in synaptic signaling onto ARH-POMC neurons, and that altering central CF-RELN levels can impact food intake and body weight. (244)
Authors: Kim K, Yang H, Na E, Lee H, Jang OJ, Yoon HJ, Oh HS, Ham BJ, Park SC, Lin SK, Tan CH, Shinfuku N, Park YC Abstract Based on Korean data from the Research on Asian Psychotropic Prescription Pattern for Bipolar Disorder, this study tried to present prescription patterns in biopolar disorder (BD) and its associated clinical features. Based on the information obtained from the study with structured questions, the tendency of prescription pattern was studied and analyzed. Polypharmacy was predominant, including simple polypharmacy in 51.1% and complex polypharmacy in 34.2% of patients. Subjects associated with ...
Throughout our lives, we are inspired by many people, from our parents to our teachers to celebrities to great thinkers of the past and present. And sometimes, we find ourselves being an inspiration for others. Also, sometimes, this fact surprises us. In this episode, Gabe and Michelle talk about both being inspired by others and how it feels to be an inspiration to others. SUBSCRIBE &REVIEW “In the right light, all of us are fantastic. In the right, light we all suck.” – Gabe Howard Highlights From ‘Inspiration’ Episode [00:30] Is Michelle amazing? [3:30] Is Ga...
Previous studies have identified shifts in gut microbiota associated with AAP-treatment, which may link AAPs to metabolic burden. Dietary prebiotics, like resistant starch (RS) may be beneficial in obesity and glucose regulation, but little is known mechanistically about its ability to modify gut microbiota in AAP-treated individuals. This investigation was undertaken to mechanistically delineate the effects of AAP-treatment and RS on gut microbiota in a psychiatric population.
Bipolar Disorder (BD) has been associated with multiple phenotypic traits, including obesity. We previously performed genome-wide association studies (GWAS) for BMI-dependent BD risk and identified a genome-wide significant SNP mapped to the TCF7L2 gene. This signal was replicated in an independent cohort. TCF7L2 encodes a transcription factor in the Wnt/beta-catenin pathway. Genetic polymorphisms in TCF7L2 have been associated with type-2 diabetes risk. However, the role of TCF7L2 in neuropsychiatric disorders like BD is not well understood.
Obesity, an important cardiovascular risk factor (CVRF), is associated with important clinical characteristics of bipolar disorder (BD) among both adults and youth. Although previous task-based and resting state functional magnetic resonance imaging (fMRI) studies support alterations in the reward circuit in obesity and BD independently, patterns of altered resting state functional connectivity (rsFC) that link obesity and BD remain unclear.
Conditions: Obesity; Ketogenic Dieting; Metabolic Syndrome; Bipolar Disorder; Schizophrenia; Weight Gain; Psychotropic Drug, Unspecified Causing Adverse Effects in Therapeutic Use Intervention: Other: LCHF, Ketogenic Diet Sponsors: Stanford University; Obesity Treatment Foundation Recruiting
Abstract Both reward sensitivity and impulsivity are related to the development and course of bipolar spectrum disorders (BSDs) and have been implicated in other disorders and negative functional outcomes such as substance abuse, obesity, suicidal behaviors, and risk-taking. Furthermore, according to the transactional component of the Behavioral Approach System (BAS)/reward hypersensitivity theory of BSDs, people with reward hypersensitivity should experience more BAS-relevant events, and thus, are more vulnerable to mood symptoms and episodes via stress generation. Impulsivity may exacerbate stress generation in ...