Intratumoral Heterogeneity of ALK-Rearranged and ALK/EGFR Coaltered Lung Adenocarcinoma [Thoracic Oncology]
Conclusion
Intratumoral genetic heterogeneity was demonstrated to coexist with histologic heterogeneity in both single-driver and ALK/EGFR coaltered LADCs. Altered oncogenic drivers in spatially separated subclones of the same tumor may be different.
Source: Journal of Clinical Oncology - Category: Cancer & Oncology Authors: Cai, Lin, Wu, Li, Zhao, Zheng, Chuai, Fei, Zhou, Hirsch Tags: Translational Oncology, Cancer Biomarkers Thoracic Oncology Source Type: research
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