New Lung Cancer Drugs Raise Hope for Mesothelioma Patients

The U.S. Food and Drug Administration (FDA) recently granted approval for immunotherapy drugs Keytruda and Opdivo to fight non-small cell lung cancer, raising the hopes of patients with malignant pleural mesothelioma. Drugmakers Merck &Co. and Bristol-Myers Squibb manufacture Keytruda (pembrolizumab) and Opdivo (nivolumab), respectively. Both drugs target PD-1 and PD-L1, specific proteins that block a body's immune system from attacking the cancer cells. Those same proteins were identified in a subset of mesothelioma patients with the shortest survival times. The University of Chicago Comprehensive Cancer Center recently started the only phase II mesothelioma clinical trial for Keytruda. Meanwhile, the Netherlands Cancer Institute in Amsterdam announced in July the first mesothelioma clinical trial for Opdivo. Both drugs were already approved for other cancers, and they are now being tested in numerous clinical trials across the U.S. Opdivo has shown a promising response rate with cancers of the bladder, kidney, head and neck. Immunotherapy Cancer Drugs Work Best in Synergy Cancer researchers believe that immunotherapy drugs, such as Keytruda and Opdivo, can be utilized most effectively in a combined effort, also known as synergy, with other drugs as adjuvant treatment to eliminate remaining cancer cells after surgery. For example, the FDA approved Opdivo in 2014 for use in combination with Yervoy, a skin cancer drug, as an immunotherapy strategy for advanced mel...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: Treatment & Doctors Source Type: news

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CONCLUSIONS: localized or diffused hard-ligneous vaginal areas with Cork Wall sign represent the typical sign of disease presentation. PeNHVL is characterized by a very high sensitivity to chemotherapy and very favourable prognosis; therefore, radical surgery is not indicated. Histotype characterization is crucial to identify those uncommon variants associated with a less favorable clinical outcome. PMID: 30656635 [PubMed - as supplied by publisher]
Source: Histology and Histopathology - Category: Cytology Tags: Histol Histopathol Source Type: research
Authors: Chen SW, Xia HX, Fan QQ, Xie AW, Yu Y Abstract Obesity is an epidemic issue associated with low-grade inflammation and in most of the cases with poor iron condition that influences nearly every community. The present research experiment was designed to inspect the consequences of obesity on the micro architecture of heart and kidney tissues as well as on the expression of mRNA of some hepatic genes like Hepcidin, Transferrin and TNF-α in association with their role in iron regulation and proinflammatory responses in the body. Two tentative groups of Rattus norvegicus (each supplied with different pro...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Authors: Capodiferro S, Calabrese L, Maffini F, Cascardi E, Favia G, Maiorano E Abstract Oral squamous cell carcinoma in patients under 20 years of age is extremely rare, the alveolar gingiva being the most frequently affected site. The metachronous occurrence (eight years later) of a dentinogenic ghost cell tumour of the anterior maxilla in the same patient has never been previously reported. The patient had been diagnosed with a poorly differentiated squamous cell carcinoma of the ventral tongue when 12 years of age and was treated by en-block resection with functional neck dissection. Eight years later, he showe...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Authors: Bobrowska-Korczak B, Skrajnowska D, Seidel K, Bielecki W, Gadzinski B Abstract The aim of the present study was to assess the effect of zinc and copper, separately or in combination with resveratrol, on the concentration of 15-hydroxyeicosatetraenoic acid (15-HETE) in urine of rats with mammary cancer (adenocarcinoma) induced with 7,12- dimethyl-1,2-benz[a]anthracene (+ DMBA). The research focused on the kinetics of alterations in urinary 15-HETE at the early stage of carcinogenesis, as well as on the influence of dietary factors on the process. The content of 15-hydroxyeicosatetraenoic acid in the rats' u...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Authors: Mistretta FA, Carrion DM, Nazzani S, Vásquez JL, Fiori C, De Cobelli O, Porpiglia F, Esperto F Abstract Upper tract urinary carcinoma (UTUC) and bladder cancer (BCa) share similar biological, histological and pathological characteristics. These resemblances could explain the high rate of synchronous and metachronous tumours affecting both upper urinary tract and bladder. In patients affected by primary UTUC bladder recurrence is quite common and it represents one of the major concerns during the follow-up of patients who underwent radical nephro-ureterectomy. Conversely, UTUC recurrence after primar...
Source: Minerva Urologica e Nefrologica - Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research
Authors: Russo F, Manfredi M, Panebianco V, Armando E, De Luca S, Mazzetti S, Giannini V, Mele F, Bollito E, Appendino E, Regge D, Porpiglia F Abstract BACKGROUND: The knowledge of tumour location and extension can allow a modulated radical prostatectomy in order to minimize positive surgical margins and reduce functional morbidity after surgery in patients with prostate cancer (PCa). Multiparametric (mp) magnetic resonance imaging (MRI) could allow the assessment of tumour extension and of its relationship with external structures. Aim of this study is to propose a new radiological Wheeler (rW) staging system appl...
Source: Minerva Urologica e Nefrologica - Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research
(MedPage Today) -- Low response rate with pembrolizumab in previously treated tumors
Source: MedPage Today Gastroenterology - Category: Gastroenterology Source Type: news
CONCLUSIONS: In oncological patients, despite its high detection rate, 18F-FDG PET/CT, as well as any other clinico-anatomical features, cannot distinguish whether a malignant solitary pulmonary nodule is a metachronous lung cancer or a metastasis, supporting the need of histological differential diagnosis. PMID: 30654605 [PubMed - as supplied by publisher]
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research
Abstract Objective: To investigate the anti-tumor effects and the mechanism of the compound 13-chlorine-3, 15-dioxy-gibberellic acid methyl ester (GA-13315) in lung adenocarcinoma in vitro and in vivo. Methods: The antiproliferative effect of GA-13313 on the A549 cell line was determined by MTT (3-[4, 5-dimethylthiazol-2-yl]-2, 5 diphenyl tetrazolium bromide) assay. A xenograft model of A549 was established to evaluate the anti-tumor effect and histopathological examination was performed to assess the toxicity of GA-13315. Apoptosis was detected by TUNEL staining in tissues and flow cytometry in cells; activa...
Source: Cellular and Molecular Biology Letters - Category: Biochemistry Authors: Tags: Cell Mol Biol Lett Source Type: research
Authors: Hofmann S, Bellmann-Sickert K, Beck-Sickinger AG Abstract As a very abundant neuropeptide in the brain and widely distributed peptide hormone in the periphery, neuropeptide Y (NPY) appears to be a multisignaling key peptide. Together with peptide YY, pancreatic polypeptide and the four human G protein-coupled receptor subtypes hY1R, hY2R, hY4R and hY5R it forms the NPY/hYR multiligand/multireceptor system, which is involved in essential physiological processes as well as in human diseases. In particular, NPY-induced hY1R signaling plays a central role in the regulation of food intake and stress response as...
Source: Biological Chemistry - Category: Chemistry Tags: Biol Chem Source Type: research
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