New Lung Cancer Drugs Raise Hope for Mesothelioma Patients
The U.S. Food and Drug Administration (FDA) recently granted approval for immunotherapy drugs Keytruda and Opdivo to fight non-small cell lung cancer, raising the hopes of patients with malignant pleural mesothelioma. Drugmakers Merck &Co. and Bristol-Myers Squibb manufacture Keytruda (pembrolizumab) and Opdivo (nivolumab), respectively. Both drugs target PD-1 and PD-L1, specific proteins that block a body's immune system from attacking the cancer cells. Those same proteins were identified in a subset of mesothelioma patients with the shortest survival times. The University of Chicago Comprehensive Cancer Center recently started the only phase II mesothelioma clinical trial for Keytruda. Meanwhile, the Netherlands Cancer Institute in Amsterdam announced in July the first mesothelioma clinical trial for Opdivo. Both drugs were already approved for other cancers, and they are now being tested in numerous clinical trials across the U.S. Opdivo has shown a promising response rate with cancers of the bladder, kidney, head and neck. Immunotherapy Cancer Drugs Work Best in Synergy Cancer researchers believe that immunotherapy drugs, such as Keytruda and Opdivo, can be utilized most effectively in a combined effort, also known as synergy, with other drugs as adjuvant treatment to eliminate remaining cancer cells after surgery. For example, the FDA approved Opdivo in 2014 for use in combination with Yervoy, a skin cancer drug, as an immunotherapy strategy for advanced mel...
Conclusions Monotony, managing symptoms, and isolation were the hardest obstacles for AYAs throughout the process. Families discussed managing their care activities by developing routines that got easier with time. Implications for Practice Nurses play an instrumental role in AYA self-management practices by providing information, education, and social support. Psychosocial issues were prominent in the self-management process and should be addressed in future research and interventions with AYAs and caregivers.
Background: Despite pharmacological treatment, chemotherapy-induced nausea and vomiting (CINV) are observed in patients. Objective: This quasi-randomized controlled pilot study evaluated the feasibility and preliminary effects of massage and inhalation aromatherapies on chemotherapy-induced acute nausea/vomiting. Methods: Seventy-five patients with breast cancer were randomly grouped into 1 of 3 groups: massage (n = 25), inhalation (n = 25), and control (n = 25). The patients in the massage group received 20-minute aromatherapy foot massage, whereas those in the inhalation group received 3-minute inhalation aromath...
Conclusions: Key findings of this study involved function-related outcomes and self-efficacy. Implications for Practice: Because these outcomes are particularly meaningful for patients, the integration of ANtiPain to routine clinical practice may be substantial. A larger study will be based on these findings.
Conclusions: A home-based exercise program is relatively feasible and safe and may improve muscle strength but not bone outcomes. Implications for Practice: Given the importance of preventing cancer treatment–induced bone loss among PCSs receiving ADT, a home-based exercise intervention can be considered, but further trials with a larger sample are required to determine its effect for bone outcomes.
Conclusion: Young people with cancer want age-appropriate lifestyle information on a range of topics delivered in multiple formats at various time points. Implications for Practice: Health professionals working with TYA cancer survivors should address young peoples’ lifestyle information needs throughout the cancer care pathway and support young people to foster the confidence to make, and sustain, positive lifestyle behavior changes.
Background Nurses’ caring behaviors are central in the quality of care of patients undergoing sophisticated chemotherapy protocols. However, there is a scarcity of research regarding these behaviors in non–Anglo-Saxon countries. Objective The aim of this study was to explore caring behaviors that nurses perceive as important in caring for patients in Greece receiving chemotherapy. Methods We used a mixed-methods design, including a survey in 7 oncology wards in 3 cancer hospitals in Attica, Greece, and a subsequent qualitative focus group investigation. Caring behaviors were explored through the Caring ...
Conclusions Voluntary participation in breast health–seeking behaviors is a culturally sensitive topic. The qualitative methodology allowed this sensitive topic and its different aspects to be explored. The findings indicated that the major source of support for women was their husband’s behavior toward breast health–seeking actions. Family cohesion and love among couples were identified as strong determinant factors pertaining to husband’s supportive behaviors. Implications for Practice The study findings provided deeper understanding about the effective factors related to a husband’s ro...
Conclusions: This study suggests a clinical benefit of EP related to improved toxicity management of sorafenib that resulted in fewer dose reductions. Implications for Practice: Patients treated with sorafenib may benefit from an EP. Different types of EP should be compared prospectively, focusing on patients’ quality of life.
Conclusions: High-risk groups for anal cancer should be targeted for preventative measures as part of a cancer prevention plan to decrease the personal and clinical burden associated with anal cancer. Implications for Practice: Cancer prevention is a multistep process that requires screening and follow-up efforts, where healthcare providers play a vital role in these efforts. Findings from this study can inform strategies to improve screening and follow-up rates in HIV-infected individuals.
No abstract available
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