Nanoparticle delivery maximizes drug defense against bioterrorism agent

Scientists from the California NanoSystems Institute at UCLA have developed a nanoparticle delivery system for the antibiotic moxifloxacin that vastly improves the drug’s effectiveness against pneumonic tularemia, a type of pneumonia caused by inhalation of the bacterium Francisella tularensis. The study, which appears in the journal ACS Nano, shows how the nanoparticle system targets the precise cells infected by the bacteria and maximizes the amount of drug delivered to those cells. Jeffrey Zink, distinguished professor of chemistry and biochemistry and a senior author on the study, developed the mesoporous silica nanoparticles used for drug delivery. Zink and his research team conducted an exhaustive process to find the best particle for the job. “The nanoparticles are full of deep empty pores,” Zink said. “We place the particles in drug solution overnight, filling the pores with drug molecules. We then block the pore openings on the nanoparticle’s surface with molecules called nanovalves, sealing the drug inside the nanoparticle.” When the drug-bearing nanoparticles are injected into the infected animal, in this case a mouse, the drug stays in the nanoparticles until they reach their target: white blood cells called macrophages. Macrophages ingest nanoparticles into compartments that have an acidic environment. The nanovalves, which are designed to open in response to the more acidic surroundings, then release the drug. “We t...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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This study will be conducted in Tongji Hospital, Caidian, Wuhan, People ’s Republic of China.Intervention and comparatorThe experimental group will be given the nationally recommended standard medical treatment + ultra-short-wave diathermy treatment. Ultra-short-wave therapy treatment will be performed through application of ultra-short-wave therapy machine electrodes on the anterior and posterior parts of the trunk for 10 minutes, twice a day for 12 consecutive days. The comparator will be the control, not receiving ultra-short-wave therapy, and will be given only the nationally recommended standard medical treatmen...
Source: Trials - Category: Research Source Type: clinical trials
AbstractSince December 2019, the Coronavirus Disease (COVID-19) pandemic has caused world-wide turmoil in a short period of time, and the infection, caused by SARS-CoV-2, is spreading rapidly. AI-driven tools are used to identify Coronavirus outbreaks as well as forecast their nature of spread, where imaging techniques are widely used, such as CT scans and chest X-rays (CXRs). In this paper, motivated by the fact that X-ray imaging systems are more prevalent and cheaper than CT scan systems, a deep learning-based Convolutional Neural Network (CNN) model, which we call Truncated Inception Net, is proposed to screen COVID-19...
Source: Australasian Physical and Engineering Sciences in Medicine - Category: Biomedical Engineering Source Type: research
Authors: Esposito S, Bianchini S, Argentiero A, Neglia C, Principi N Abstract INTRODUCTION: The definition of acute lower respiratory tract infection (LRTI) includes any infection involving the respiratory tract below the level of the larynx. In children, the most common acute LRTIs, and those with the greatest clinical relevance, are community-acquired pneumonia (CAP), bronchiolitis, bronchitis and tuberculosis (TB). The clinical relevance of LRTIs implies that they must be addressed with the most effective therapy. Antibiotics and antivirals play an essential role in this regard. AREAS COVERED: In this paper,...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
ConclusionAnti-TNF-α agents treatment has high effectiveness including efficient inflammation remission, satisfactory VA improvement, obvious CMT reduction, and significant CS-sparing effects. Although some drug-related AEs were reported, the incidence of severe AEs was acceptable. Anti-TNF-α agents treatment is a promising option for controlling BD-associated uveitis.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Herein, we report a case of a diffuse micronodular form of cryptogenic organizing pneumonia (COP) that was diagnosed via transbronchial biopsy (TBB) and resolved spontaneously within a few months. Our case highlights that diffuse micronodular pattern of OP (MNOP) may resolve spontaneously similar to other forms of OP, and mild cases may be under ‐recognized. Furthermore, careful observation could be an option for managing MNOP with mild and non‐progressive symptoms. AbstractOrganizing pneumonia (OP) is a common interstitial lung disease, pathologically characterized by polypoid granulation tissue in the alveolar ducts ...
Source: Respirology Case Reports - Category: Respiratory Medicine Authors: Tags: Case Report Source Type: research
Semin Respir Crit Care Med DOI: 10.1055/s-0040-1710583According to World Health Organization estimates, tuberculosis (TB) and lower respiratory tract infections (LRTIs) are both among the top 10 global causes of death. TB and community-acquired pneumonia (CAP), if mortality estimates are combined, would rank as the third most common cause of death globally. It is estimated that each year there are approximately 10 million new cases of TB that are associated with approximately 1.2 million deaths, and almost 450 million new episodes of LRTI (synonymous with CAP) with approximately 4 million associated deaths. Globally, Strep...
Source: Seminars in Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Review Article Source Type: research
In conclusion, opportunistic infections are the main reason of hospitalization in PLWH. PMID: 32547790 [PubMed]
Source: AIDS Research and Treatment - Category: Infectious Diseases Tags: AIDS Res Treat Source Type: research
CONCLUSION: The aetiology of ARDS in tropical medical setting is infection related. ARDS due to scrub typhus appeared to be mild with good outcome. PMID: 32539030 [PubMed - in process]
Source: Journal of the Royal College of Physicians of Edinburgh - Category: General Medicine Tags: J R Coll Physicians Edinb Source Type: research
Abstract Introduction. Pneumonia is highly prevalent in intensive care units (ICUs), with high associated mortality. Empirical treatment prioritizes breadth of coverage while awaiting laboratory diagnosis, often at the expense of antimicrobial stewardship. Microarrays use multiple parallel polymerase chain reactions to enable a rapid syndromic approach to laboratory diagnosis.Aim. To evaluate the clinical and laboratory implications of introducing a bespoke 22-pathogen TaqMan Array Card (TAC) for rapid pathogen detection in deep respiratory samples from adult ICUs.Methodology. TAC results from all ICU patients pro...
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research
Publication date: Available online 16 June 2020Source: Microbes and InfectionAuthor(s): Meili Wei, Yongjie Zhao, Zhuoyu Qian, Biao Yang, Jun Xi, Jun Wei, Bikui Tang
Source: Microbes and Infection - Category: Infectious Diseases Source Type: research
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