Blood test could help improve prostate cancer outcomes

ConclusionAbiraterone is an expensive drug, which can work well in some men, but not in others. NICE is yet to make a decision on whether it can be widely used on the NHS because of cost concerns. The cost would be far more palatable if it was possible to tell in advance which men would benefit from using the drug.This is an early-stage study that establishes an apparent relationship between certain gene mutations detectable on blood tests and the chances of a man benefiting from abiraterone after his cancer has progressed and is no longer responding to first treatments.The results need to be confirmed in larger studies. The researchers suggest prospective clinical trials, in which men are selected for treatment on the basis of their test results, to see if this strategy helps men get the treatment most suitable for their tumour. This would be a big step towards "personalised medicine" for prostate cancer, in which treatments can be targeted at those most likely to benefit.However, we do need to be cautious. Only 17 of the men had a complete response to abiraterone, and many who had no gene mutations related to androgen receptors either had a small response, or no response to treatment. The study seems to identify a group who are less likely to benefit from treatment, but it does not follow that everyone who isn't in that group will benefit. We also don't know the effect of treating men who do have gene mutations with other types of treatment. It may be that th...
Source: NHS News Feed - Category: Consumer Health News Tags: Cancer Genetics/stem cells Medical practice Source Type: news

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Authors: Gallicchio R, Mastrangelo PA, Nardelli A, Mainenti PP, Colasurdo AP, Landriscina M, Guglielmi G, Storto G Abstract Radium-223 dichloride (223Ra) is the first, recently approved, α-particle-emitting radiopharmaceutical for the treatment of patients with bone metastases in castration-resistant prostate cancer (CRPC) and no evidence of visceral metastases. We explored MEDLINE, relevant congresses, and websites for data on 223Ra and prostate cancer therapies, focusing on therapeutic strategies and timing, bone metastases, and diagnostic assessment. 223Ra represents the only bone-targeting agent that has ...
Source: Tumori - Category: Cancer & Oncology Tags: Tumori Source Type: research
ConclusionsLong-term QOL and late toxicity are favorable following postprostatectomy radiation therapy. Identifiable clinical and dosimetric risk factors may guide decision making to optimize urinary, sexual, and bowel function.Patient summaryThe following study provides a detailed report of favorable patient-reported quality of life and late side-effect profiles of radiation therapy following surgery for localized prostate cancer. Our findings provide patients guidance on what symptoms to expect if they are planning to undergo radiation therapy in this setting. It also allows physicians to counsel patients appropriately, ...
Source: European Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 18 May 2019Source: Journal of Herbal MedicineAuthor(s): Richard Komakech, Youngmin KangAbstractMedicinal plants have been an integral part of the healthcare system for centuries. Prunus africana, an evergreen plant of the family Rosaceae in sub-Saharan Africa, has been used to treat numerous diseases and disorders since time immemorial. Over the past decades, several ethnomedicinal surveys were conducted in many communities across Africa which validated the use of P. africana in traditional medicine. The increased interest in P. africana across the globe has led to several pharmacological...
Source: Journal of Herbal Medicine - Category: Complementary Medicine Source Type: research
Publication date: Available online 18 May 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Zoran CuligAbstractEpithelial to mesencyhmal transition (EMT) has a central role in tumor metastasis and progression. EMT is regulated by several growth factors and pro-inflammatory cytokines. The most important role in this regulation could be attributed to transforming growth factor-β (TGF-β). In breast cancer, TGF-β effect on EMT could be potentiated by Fos-related antigen, oncogene HER2, epidermal growth factor, or mitogen-activated protein kinase kinase 5 – extracellular-re...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - Category: Molecular Biology Source Type: research
Abstract Early diagnosis and management of prostate cancer is crucial to providing safe, high-quality care to patients. Understanding the complexities of the signs and symptoms of prostate cancer can help nurse practitioners (NPs) make timely decisions to assess a patient's complaints and consider differential diagnoses. Acting on diagnostics, NPs can guide patients through treatment strategies to ensure positive health outcomes. PMID: 31099786 [PubMed - in process]
Source: Clinical Journal of Oncology Nursing - Category: Nursing Authors: Tags: Clin J Oncol Nurs Source Type: research
ConclusionsThree-dimensional printing shows revolutionary potentials for patient counseling, pre- and intraoperative surgical planning, and education in urology. Together with the “patient-tailored” presurgical planning, it puts the basis for 3D-bioprinting technology. Although costs and “production times” remain the major concerns, this kind of technology may represent a step forward to meet patients’ and surgeons’ expectations.Patient summaryThree-dimensional printing has been used for several purposes to help the surgeon better understand anatomy, sharpen his/her skills, and guide the...
Source: European Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 17 May 2019Source: European UrologyAuthor(s): Bingzhi Wang, Huan Deng, Lan Cao
Source: European Urology - Category: Urology & Nephrology Source Type: research
Up to 60% of patients (pts) with prostate cancer that extends beyond the prostatic capsule will have positive resection margins following radical prostatectomy. Post-operative radiation therapy (PostOp) is routinely offered to those pts. Although this improves local control and overall survival, it results in significantly more late toxicity than surgery alone. Pre-operative radiation therapy (PreOp) has become the standard for soft tissue sarcoma and rectal cancer, improving local control and reducing toxicity compared to PostOp.
Source: Journal of Medical Imaging and Radiation Sciences - Category: Radiology Authors: Source Type: research
Most cancers that metastasize to the cervical lymph nodes are from the upper aerodigestive tract. We use a case report and systematic literature review to highlight a very rare example of atypical metastatic spread to the cervical lymph nodes from advanced prostate cancer without involvement of other lymph node groups.
Source: Journal of Medical Imaging and Radiation Sciences - Category: Radiology Authors: Source Type: research
Authors: Bobrowska-Korczak B, Skrajnowska D, Kiss AK, Wrzesien R, Bielecki W, OrzoƂ A, Zebrowski P, Bialek S Abstract Prostate cancer continues to be a major cause of morbidity and mortality in men around the world. The data concerning the antioxidant status and the degree of lipid peroxidation at the moment of the initiation of cancer is limited. The aim of this research is to assess the effect of selected minerals (zinc, selenium, iron, copper and calcium) on the growth of the neoplastic process and the concentrations of selected biomarkers of the oxidative damage in rats with implanted prostate cancer cells. It...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
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