Blood test could help improve prostate cancer outcomes

ConclusionAbiraterone is an expensive drug, which can work well in some men, but not in others. NICE is yet to make a decision on whether it can be widely used on the NHS because of cost concerns. The cost would be far more palatable if it was possible to tell in advance which men would benefit from using the drug.This is an early-stage study that establishes an apparent relationship between certain gene mutations detectable on blood tests and the chances of a man benefiting from abiraterone after his cancer has progressed and is no longer responding to first treatments.The results need to be confirmed in larger studies. The researchers suggest prospective clinical trials, in which men are selected for treatment on the basis of their test results, to see if this strategy helps men get the treatment most suitable for their tumour. This would be a big step towards "personalised medicine" for prostate cancer, in which treatments can be targeted at those most likely to benefit.However, we do need to be cautious. Only 17 of the men had a complete response to abiraterone, and many who had no gene mutations related to androgen receptors either had a small response, or no response to treatment. The study seems to identify a group who are less likely to benefit from treatment, but it does not follow that everyone who isn't in that group will benefit. We also don't know the effect of treating men who do have gene mutations with other types of treatment. It may be that th...
Source: NHS News Feed - Category: Consumer Health News Tags: Cancer Genetics/stem cells Medical practice Source Type: news

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PROSTATE cancer is sometimes only diagnosed when it has spread to other parts of the body, at which point it can be hard to treat. Could exercise help stop the disease from spreading?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Conclusiones: El tratamiento de la OMAM depende del estadio de la enfermedad; la mandibulectomía es un tratamiento efectivo en el estadio 3 y la secuestrectomía en el estadio 2; el estadio 1 suele controlarse con tratamiento conservador.ABSTRACT Introduction: Bisphosphonates are a family of drugs used to inhibit bone resorption. One of their secondary effects is osteonecrosis of the jaws (ONJ). In 2010, scientists began to publish cases of osteonecrosis of the jaws associated with a new drug, denosumab. In 2014 it was recommended to change the name of ONJ to medication-related osteonecrosis of the jaws (MONJ)...
Source: Revista Espanola de Cirugia Oral y Maxilofacial - Category: ENT & OMF Source Type: research
[Daily News] BUKOBA Regional Referral Hospital has acquired essential devices to screen cervical and prostate cancer in efforts to improve health delivery to majority of the population.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Biochemical recurrence predicts survival in men with prostate cancer who have additional specific clinical risk factors, according to a systematic review.Reuters Health Information
Source: Medscape Pathology Headlines - Category: Pathology Tags: Hematology-Oncology News Source Type: news
Prostate cancer is a major malignancy in males. TMPRSS2-ERG is a high-frequency fusion gene expressed in prostate cancer and plays a vital role in carcinogenesis. Recent studies showed that TMPRSS2-ERG is a poten...
Source: Cancer Cell International - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
ConclusionOur results suggest that glucose levels may influence prostate cancer survival, but further studies using repeated measurements are needed to further elucidate how glucose levels may influence prostate cancer progression.
Source: Cancer Causes and Control - Category: Cancer & Oncology Source Type: research
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Source: Cancer Science - Category: Cancer & Oncology Authors: Tags: Original Article Source Type: research
SummaryMagnetic resonance imaging (MRI) of the prostate has become the gold standard for visualization of prostate cancer. Prostate MRI is usually performed as multiparametric MRI (mpMRI). Since mpMRI has several drawbacks, a  biparametric MRI (bpMRI) of the prostate has been proposed. Many studies have been published on mpMRI and bpMRI in recent years. This short review offers an overview of the latest developments in this rapidly evolving field of research.
Source: Memo - Magazine of European Medical Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 9 November 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Christina C. Pierre, Shawn M. Hercules, Clayton Yates, Juliet M. DanielAbstractThe POZ-ZF transcription factor Kaiso was discovered two decades ago as a binding partner for p120ctn. Since its discovery, roles for Kaiso in diverse biological processes (epithelial-to-mesenchymal transition, apoptosis, inflammation) and several signalling pathways (Wnt/β-catenin, TGFβ, EGFR, Notch) have emerged. While Kaiso's biological role in normal tissues has yet to be fully elucidated, Kaiso has been incre...
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - Category: Cancer & Oncology Source Type: research
This study was designed to produce the optimal Alg-g-P(NIPAAm) hydrogel with respect to localised delivery of DNA nanoparticles as a potential medical device for those with castrate resistant prostate cancer (CRPC). Given that CRPC typically disseminates to bone causing pain, morbidity and a plethora of skeletal related events, a copolymer based hydrogel was designed to for long term release of therapeutic DNA nanoparticles.The nanoparticles were comprised of plasmid DNA (pDNA), complexed with an amphipathic cell penetrating peptide termed RALA that is designed to enter cells with high efficiency. Alginate MW and M/G ratio...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
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