Erlotinib Fails at Chemoprevention of Oral CancerErlotinib Fails at Chemoprevention of Oral Cancer

In the first precision-based chemoprevention study, erlotinib failed to significantly prevent the development of oral cancer in patients with oral premalignant lesions. Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

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Periodontitis affects nearly half of Americans ages 30 and older, and in its advanced stages, it could lead to early tooth loss or worse. Recent studies have shown that periodontitis could also increase risk of  heart disease and Alzheimer’s disease.A team of UCLA researchers has developed methods that may lead to more effective and reliable therapy for periodontal disease — ones that promote gum tissue and bone regeneration with biological and mechanical features that can be adjusted based on treatment needs. Thestudy is published online in ACS Nano.Periodontitis is a chronic, destructive diseas...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Tongue cancer patients suffer severe, chronic pain driven by oral cancer-induced activation of sensory neurons innervating the oral cavity. However, the impact of sensory neurotransmission on oral carcinogenesis is understudied. Local neurotransmitter release from sensory neurons innervating the cancer has been linked to cancer growth and immune suppression. We hypothesize that oral cancer-induced neurotransmitter release from trigeminal sensory neurons (TGNs) promotes oral cancer proliferation and suppresses the immune response.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
Patients with head and neck cancer can experience pain that impacts quality of life. Therefore, we developed a patient-reported Electronic Patient Visit Assessment (ePVA) for early detection and intervention for pain. Patients use interactive touch screen technology to indicate presence and location of pain and functional limitations (eg. limited mobility of mouth, neck, shoulders). To test clinical usefulness of the ePVA, after informed consent, 72 participants with head and neck cancer completed the ePVA one time before, during, or after treatment at an academic cancer center in northeastern United States between August ...
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
Authors: Mougeot JC, Stevens CB, Almon KG, Paster BJ, Lalla RV, Brennan MT, Mougeot FB Abstract Head and neck cancer (HNC) therapy often leads to caries development. Our goal was to characterize the oral microbiome of HNC patients who underwent radiation therapy (RT) at baseline (T0), and 6 (T6) and 18 (T18) months post-RT, and to determine if there was a relationship with increased caries. HOMINGS was used to determine the relative abundance (RA) of>600 bacterial species in oral samples of 31 HNC patients. The DMFS score was used to define patient groups with tooth decay increase (DMFS[+]) or no increase (...
Source: Journal of Oral Microbiology - Category: Microbiology Tags: J Oral Microbiol Source Type: research
RESUMO: Introdu ção: O câncer de boca e o câncer de orofaringe são doenças influenciadas por fatores socioeconômicos. O risco de desenvolver essas doenças aumenta com a idade, e a maioria dos casos ocorre em idosos, com elevadas taxas de mortalidade. O objetivo deste estudo foi analisar a influência dos í ndices socioeconômicos municipais nas taxas de mortalidade por câncer de boca (CB) e de orofaringe (CO) em idosos nas 645 cidades do estado de São Paulo, Brasil, nos anos de 2013 a 2015. Método: Dados secundários de ó...
Source: Revista Brasileira de Epidemiologia - Category: Epidemiology Source Type: research
In this study, a natural antimicrobial cationic peptide of epsilon-poly-l-lysine (EPL) decorated ordered mesoporous silica (SBA-15) was facilely prepared for the efficient loading of antifungal itraconazole (ITZ) drugs. The characterized mesoporous SBA-15/EPL/ITZ composite exhibited remarkable antifungal performance against Aspergillus fumigatus as a model mold, which was attributed to synergistic antifungal activities of ITZ and EPL in the mesopores. Moreover, the in vitro release behaviors of ITZ in the composite nanoexcipients both in simulated gastric fluid and fasted state simulated intestinal fluid were studied. The ...
Source: Appl Human Sci - Category: Physiology Authors: Tags: Mater Sci Eng C Mater Biol Appl Source Type: research
DISCUSSION: The selected formulation (F6) has a mean particle size of 79.7 nm with PDI 0.098 and the minimum viscosity of 16.42 cps with % transmittance of 1.332 with maximum drug release of 96.968% in 32 h as compared to DOX alone. Stability data showed stable emulsion in both 250C and -40C. F6 showed improved efficacy in HepG2 cells by cytotoxicity, showed significant results p
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
Excessive consumption of beverages sweetened with high-fructose corn syrup (HFCS) is associated with obesity and with an increased risk of colorectal cancer. Whether HFCS contributes directly to tumorigenesis is unclear. We investigated the effects of daily oral administration of HFCS in adenomatous polyposis coli (APC) mutant mice, which are predisposed to develop intestinal tumors. The HFCS-treated mice showed a substantial increase in tumor size and tumor grade in the absence of obesity and metabolic syndrome. HFCS increased the concentrations of fructose and glucose in the intestinal lumen and serum, respectively, and ...
Source: ScienceNOW - Category: Science Authors: Tags: Medicine, Diseases reports Source Type: news
ConclusionJudgment of TBS has a good overall inter-observer agreement and good to excellent intra-observer agreement, which guarantees its utilization and popularity in detecting OPMDs and oral cancer.Clinical relevanceTo our knowledge, this is the first study to investigate the inter- and intra-observer agreement of TBS judgment. The present results revealed a good inter-observer agreement and good to excellent intra-observer agreement, which provide a beneficial supplement to the knowledge of TBS technique.
Source: Clinical Oral Investigations - Category: Dentistry Source Type: research
Conclusions: S-1 can be safely combined with the clinically relevant dose of T-DM1 in patients with HER2-positive advanced or metastatic breast cancer. Further evaluation with a larger sample size is required for efficacy assessment.Oncology
Source: Oncology - Category: Cancer & Oncology Source Type: research
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