Raloxifene Fails to Affect Cognition in Alzheimer's Disease (CME/CE)

(MedPage Today) -- But subtle benefits can't be ruled out
Source: MedPage Today Geriatrics - Category: Geriatrics Source Type: news

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OBJECTIVES: To examine the driving variables that predict accident probability in mild dementia due to Alzheimer's disease (AD), mild cognitive impairment (MCI) and healthy older control drivers in simulated driving. To compare the three groups in mean per...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
In this study, we have investigated the role of all-trans-retinoic acid (RA) as a neuroprotective agent against Aβ 1-42-induced DNA double-strand breaks (DSBs) in neuronal SH-SY5Y and astrocytic DI TNC1 cell lines and in murine brain tissues, by single-cell gel electrophoresis. We showed that RA does not only repair Aβ 1-42-induced DSBs, as already known, but also prevents their occurrence. This effect is independent of that of other antioxidants studied, such as vitamin C, and appears to be mediated, at least in part, by changes in expression, not of the RARα, but of the PPARβ/δ and of antiamylo...
Source: Neural Plasticity - Category: Neurology Authors: Tags: Neural Plast Source Type: research
This study suggests that exercise improves cognition and neural activity by altering the numbers and distribution of hippocampal Nav in APP/PS1 mice. Long-term treadmill exercise, for about 24 weeks, starting in the preclinical stage, is a promising therapeutic strategy for preventing AD and halting its progress. PMID: 32256560 [PubMed - as supplied by publisher]
Source: Neural Plasticity - Category: Neurology Authors: Tags: Neural Plast Source Type: research
Research into cancer, heart disease, HIV, MS, Alzheimer ’s, gene therapy, opioid addiction, epilepsy, blindness — all abruptly stopped in mid-March.
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Advanced visualization and image analytics software developer Qmenta is collaborating...Read more on AuntMinnie.comRelated Reading: Qmenta appoints new CEO Qmenta wins contract for Alzheimer's trial Qmenta signs Rosen as scientific adviser
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Conditions:   Anxiety;   Anxiety Generalized;   Anxiety Disorders and Symptoms;   Caregiver Burnout Interventions:   Behavioral: Telephone Acceptance and Commitment Therapy Intervention for Caregivers;   Behavioral: minimally-Enhanced Usual Care Sponsors:   Indiana University;   Indiana Clinical and Translational Sciences Institute;   Regenstrief Institute, Inc. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Initial findings from the Anti-Amyloid Treatment in Asymptomatic Alzheimer's...Read more on AuntMinnie.comRelated Reading: PET shows cardiac meds may reduce beta-amyloid buildup Is PET really necessary to predict oncoming Alzheimer's? Study: FDG-PET reigns supreme for assessing Alzheimer's PET model tracks beta amyloid, Alzheimer's risk PET shows how women are more susceptible to Alzheimer's
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Conditions:   Anxiety;   Anxiety Generalized;   Anxiety Disorders and Symptoms;   Caregiver Burnout Interventions:   Behavioral: Telephone Acceptance and Commitment Therapy Intervention for Caregivers;   Behavioral: minimally-Enhanced Usual Care Sponsors:   Indiana University;   Indiana Clinical and Translational Sciences Institute;   Regenstrief Institute, Inc. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract Mast cells are tissue-resident immune cells that are involved in inflammation and fibrosis but also serve beneficial roles, including tissue maintenance, angiogenesis, pathogen clearance, and immunoregulation. Their multifaceted response and the ability of their mediators to target multiple organs and tissues means that mast cells play important roles in numerous conditions, including asthma, atopic dermatitis, drug sensitivities, ischemic heart disease, Alzheimer disease, arthritis, irritable bowel syndrome, infections (parasites, bacteria and viruses), and cancer. As a result, mast cells have become an ...
Source: Journal of Immunology - Category: Allergy & Immunology Authors: Tags: J Immunol Source Type: research
The first published data from the'A4'trial show strong support for amyloid as an Alzheimer's prevention target.Medscape Medical News
Source: Medscape FamilyMedicine Headlines - Category: Primary Care Tags: Neurology & Neurosurgery News Source Type: news
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