Five years after stem cell transplant complications, he’s an active teenager
Drew at 2014 Be the Match Walk in NYC. His stem cell donor lives in Germany. “It’s eye-opening to realize how fragile life really is when you’re young.” Drew D’Auteuil certainly knows whereof he speaks. He is a 16-year-old animal-loving, skiing, rowing, volleyball-playing, honor roll student and licensed driver with braces and a shock of red hair. In April 2010, five months after receiving a stem cell transplant to treat the blood disorder severe aplastic anemia, Drew suffered rare, life-threatening complications. One day Drew was biking with a friend near his New Hampshire home, suffering little more than a mild cough. The next day he was in the intensive care unit at Boston Children’s Hospital, intubated because of respiratory failure. Soon other organs were failing, too. Quick action by ICU and transplant clinicians saved the boy’s life. Although the donor stem cells that would replace his failing bone marrow with healthy marrow were engrafting well, Drew developed Idiopathic pneumonitis syndrome (IPS), a dangerous inflammation of the lungs that occasionally arises in transplant patients who receive stem cells from an unrelated donor. “IPS is a very rare but known complication of stem cell transplant, with a high fatality rate,” says Dr. Allison O’Neill, Drew’s pediatric hematologist/oncologist at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center. “Drew’s ICU and tr...
Publication date: Available online 30 May 2020Source: Life SciencesAuthor(s): Qi Fu, Zhenhai Yu
Publication date: Available online 29 May 2020Source: Life SciencesAuthor(s): Nagesh Kishan Panchal, E.P. Sabina
In this study, five machine learning algorithms and twelve types of molecular fingerprints were employed to generate QSAR discriminant models for mitochondrial toxicity. A threshold moving method was adopted to resolve the imbalance issue in the training data. Consensus of the models by an averaging probability strategy improved prediction performance. The best model has correct classification rates of 81.8% and 88.3% in ten-fold cross validation and external validation, respectively. Substructures such as phenol, carboxylic acid, nitro and arylchloride were found informative through analysis of information gain and freque...
Publication date: Available online 30 May 2020Source: Urology Case ReportsAuthor(s): Andrew Moe, Isaac Thyer, Rajalingam Sinniah, Dickon Hayne
This study is aimed at determining the prevalence of severe depression in Iranian women with breast...
Publication date: Available online 30 May 2020Source: European Journal of Surgical OncologyAuthor(s): R.H. Bhogal, P.H. Patel, S.L.F. Doran, S. Zar, J.M. Pollok, L.R. Jiao, W.H. Allum, M.A. Chaudry, S. Kumar
Publication date: Available online 29 May 2020Source: Respiratory InvestigationAuthor(s): Yoshiaki Kinoshita, Hiroshi Ishii, Yoshinobu Eishi, Keisuke Uchida, Masayo Yoshimura, Akinori Iwasaki, Masaki Fujita, Kazuki Nabeshima, Kentaro Watanabe
This study aimed to evaluate the effects of LLV on HCC development, mortality, and cirrhotic complications among patients according to their adherence to entecavir (ETV) treatment. Methods: We performed a retrospective observational analysis of data from 894 consecutive adult patients with treatment-naïve CHB undergoing ETV treatment. LLV was defined according to either persistent or intermittent episodes of
Authors: Lucioni M, Lionello M, Guida F, Sovran F, Canal F, Rizzotto G, Bertolin A PMID: 32469004 [PubMed - in process]
Authors: Rizzo D, Graziani C, Gallus R, Zannoni GF, Lucchetti D, Parrilla C, Boninsegna A, Galli J, Paludetti G, Bussu F, Sgambato A PMID: 32469002 [PubMed - in process]
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