Five years after stem cell transplant complications, he’s an active teenager

Drew at 2014 Be the Match Walk in NYC. His stem cell donor lives in Germany. “It’s eye-opening to realize how fragile life really is when you’re young.” Drew D’Auteuil certainly knows whereof he speaks. He is a 16-year-old animal-loving, skiing, rowing, volleyball-playing, honor roll student and licensed driver with braces and a shock of red hair. In April 2010, five months after receiving a stem cell transplant to treat the blood disorder severe aplastic anemia, Drew suffered rare, life-threatening complications. One day Drew was biking with a friend near his New Hampshire home, suffering little more than a mild cough. The next day he was in the intensive care unit at Boston Children’s Hospital, intubated because of respiratory failure. Soon other organs were failing, too. Quick action by ICU and transplant clinicians saved the boy’s life. Although the donor stem cells that would replace his failing bone marrow with healthy marrow were engrafting well, Drew developed Idiopathic pneumonitis syndrome (IPS), a dangerous inflammation of the lungs that occasionally arises in transplant patients who receive stem cells from an unrelated donor. “IPS is a very rare but known complication of stem cell transplant, with a high fatality rate,” says Dr. Allison O’Neill, Drew’s pediatric hematologist/oncologist at  Dana-Farber/Boston Children’s Cancer and Blood Disorders Center. “Drew’s ICU and tr...
Source: Thrive, Children's Hospital Boston - Category: Pediatrics Authors: Tags: All posts Cancer Diseases & conditions Allison O'Neill Aplastic anemia Dana-Farber/ Children's Hospital Cancer Center stem cell transplant Source Type: news

Related Links:

ConclusionThis endoscopy-based study revealed the most common histology of benign SB tumors were hamartoma and adenoma, and malignant ones were lymphomas, GISTs, adenocarcinomas and metastatic cancers. Most of them were male gender, except for GISTs, and with proximal location, except for lymphomas. Further large-scale investigation efforts are warranted to elucidate the epidemiology of SB tumors.
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
Publication date: Available online 20 July 2018Source: Alzheimer's &DementiaAuthor(s): Juan Antonio García-León, Alfredo Cabrera-Socorro, Kristel Eggermont, Ann Swijsen, Joke Terryn, Raheem Fazal, FatemehArefeh Nami, Laura Ordovás, Ana Quiles, Frederic Lluis, Lutgarde Serneels, Keimpe Wierda, Annerieke Sierksma, Mohamed Kreir, Francisco Pestana, Philip Van Damme, Bart De Strooper, Lieven Thorrez, Andreas Ebneth, Catherine M. VerfaillieAbstractTauopathies are neurodegenerative diseases characterized by TAU protein–related pathology, including frontotemporal dementia and Alzheimer's disease amo...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
ConclusionsThese findings linked the anti-tumor properties of PE with the immune microenvironment to present a reliable basis for the future practical application of PE in cervical cancer as a novel and pharmacologically safe immunotherapy strategy.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionsThe experimental results from the pharmacological research enable the validation of their traditional uses in several of the groups of diseases in the countries of origin and reveal these plants to be a valuable source for therapeutic molecules. However, more toxicity assays and clinical trials would be necessary to establish optimal and safe doses of consumption on the application of these medicinal plants.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
In conclusion, this study makes clear that lncRNA THOR is up-regulated in retinoblastoma, and its over-expression significantly enhances the malignant phenotype transformation of retinoblastoma cells through up-regulating c-myc expression via enhancing its combination with TGF2BP1 protein. Overall, our study illustrates that lncRNA THOR/c-myc molecular cascade might be another potent target for retinoblastoma treatment.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Conclusions: AEE protected against 5-Fu-induced intestinal mucositis (IM) in mice through mechanisms that involved in promoting the enterocyte proliferative activity, maintaining the integrity of tight junction proteins, inhibiting oxidative stress and ameliorating the inflammatory disturbances. Accordingly, A. agallocha may be a promising therapeutic candidate used for the prevention of IM during cancer chemotherapy.Graphical abstractThe results of this study gave a scientific support for the protection of AEE on 5-Fu-induced IM in mice through mechanisms that involved in promoting the enterocyte proliferative activity, m...
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 20 July 2018Source: American Heart JournalAuthor(s): Nuccia Morici, Fabrizio Oliva, Silvia Ajello, Miriam Stucchi, Alice Sacco, Manlio Gianni Cipriani, Michele De Bonis, Andrea Garascia, Maria Pia Gagliardone, Giulio Melisurgo, Claudio Francesco Russo, Carlo La Vecchia, Maria Frigerio, Federico PappalardoManagement of acute decompensated heart failure (ADHF) patients presenting with cardiogenic shock (CS) is not straightforward, as few data are available from clinical trials. Stabilization before left ventricle assist device (LVAD) or heart transplantation (HTx) is strongly advocated, as ...
Source: American Heart Journal - Category: Cardiology Source Type: research
Publication date: Available online 20 July 2018Source: Cancer EpidemiologyAuthor(s): E.E. Jedy-Agba, E.O. Dareng, S.N. Adebamowo, M. Odutola, E.A. Oga, F. Igbinoba, T. Otu, E. Ezeome, F. Bray, R. Hassan, C.A. Adebamowo
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 20 July 2018Source: Cancer GeneticsAuthor(s): Daja Šekoranja, Emanuela Bostjančič, Vladka Salapura, Blaž Mavčič, Jože PižemAbstractAneurysmal bone cyst (ABC) is a benign but locally aggressive, mostly pediatric neoplasm, with characteristic USP6 gene rearrangement that distinguishes it from a secondary ABC and other primary bone tumors. With the advent of next-generation sequencing (NGS) technology, several hitherto unknown USP6 fusion partners have been identified in ABC. Accordingly, we present a case of an 18-year-old male with a solid sub-periosteal primary ABC in the di...
Source: Cancer Genetics - Category: Cancer & Oncology Source Type: research
How well do you understand skin cancer risks? Test yourself with our latest quiz, and learn about USPSF recommendations for skin cancer prevention.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
More News: Anatomy | Anemia | Aplastic Anemia | Blogging | Bone Marrow Failure Syndrome (BMFS) | Boys | Cancer | Cancer & Oncology | Cancer in Adolescents | Chemistry | Children | Cough | Girls | Hematology | Hospitals | Intensive Care | Learning | Lung Transplant | Men | Pediatrics | Physical Therapy | Physiology | Psychology | Respiratory Medicine | Sports Medicine | Stem Cell Therapy | Stem Cells | Students | Transplants | Universities & Medical Training