A Pilot Study to Assess Adenosine 5'-triphosphate Metabolism in Red Blood Cells as a Drug Target for Potential Cardiovascular Protection.
A Pilot Study to Assess Adenosine 5'-triphosphate Metabolism in Red Blood Cells as a Drug Target for Potential Cardiovascular Protection. Cardiovasc Hematol Disord Drug Targets. 2015 Nov 1; Authors: Yeung P, Tinkel J, Seeto D Abstract OBJECTIVE: To study the effect of exercise preconditioning on adenosine 5'triphosphate (ATP) metabolism in red blood cells and cardiovascular protection against injury induced by isoproterenol in vivo. METHODS: Male Sprague Dawley rats (SDR) were each exercised on a treadmill for 15 minutes at 10 m/min and 10% grade (n = 7) (LowEx), or 14 m/min and 22% grade (n = 8) (VigEx). Two hours after the exercise, each rat received a single dose of isoproterenol (30 mg/kg) by subcutaneous (sc) injection. Two separate groups of SDR were used as control: One received no exercise (n = 10) (NoEx) and the other received no exercise and no isoproterenol (n = 11) (NoIso). Serial blood samples were collected over 5 hours for measurement of ATP and its catabolites by a validated HPLC. Hemodynamic recording was collected continuously for the duration of the experiment. Data were analysed using ANOVA and t-tests and difference considered significant at p
Antioxidants&Redox Signaling, Ahead of Print.
Publication date: Available online 10 December 2019Source: Seminars in Ultrasound, CT and MRIAuthor(s): Satheesh Krishna, Ashley Leckie, Ania Kielar, Robert Hartman, Ashish KhandelwalAbstractCystic renal masses are common incidental findings on cross-sectional imaging. Accurate characterisation of cystic renal masses is essential to guide management. Renal mass protocol comprises of a good quality non-contrast, corticomedullary and nephrographic phases with each phase providing complementary information for diagnosis. Attenuation measurements in different phases are central to the ‘golden-rules’ in renal mass i...
This article reviews the risks and benefits of GBCA administration.
Publication date: Available online 10 December 2019Source: European Journal of RadiologyAuthor(s): Arun Jose, Akhil Kher, Robert E. O’Donnell, Jean M. ElwingAbstractPurposeTargeted treatment for pulmonary arterial hypertension (PAH), diagnosed via right heart catheterization (RHC), has been shown to improve morbidity and mortality. Identifying characteristics that predict clinical worsening has been challenging. We sought to evaluate the role of cardiac Magnetic Resonance Imaging (CMR) as a predictor of clinical worsening in a cohort of treatment-naïve pulmonary hypertension (PH) patients.MethodsWe performed a r...
Events: Conference Call Bayer 2030 Sustainable Development ObjectivesLive today at approx. 2:00 p.m. CET (1:00 p.m. UTC): Investor Conference Call: Bayer 2030 Sustainable Development ObjectivesLink to websiteAll changes
Bayer to significantly step-up its sustainability efforts2030 target to be carbon neutral in own operations / Ambitious 2030 objectives for access to health and nutrition in low- and middle-income countries and underserved communities / Measurable sustainability targets to be incorporated into management compensationmehr ...
to the article “Attachment Disorders,” by Gail Hornor, published in the September/October 2019 issue of the Journal (Journal of Pediatric Health Care, 33, 612–622).
This article presents a case report that illustrates how evasive the diagnosis of pericardial effusion can be. The early symptoms of pericardial effusion resemble common viral conditions that can easily be overlooked. Subtle presenting symptoms and the importance of urgent multidisciplinary collaboration and emergent referral for the child with pericarditis are summarized.
This article provides an overview of CALMs, followed by a summary of several conditions associated with CALMs ranging from the most common (neurofibromatosis type 1) to rare, ring chromosome syndromes.