DBD-F induces apoptosis in gastric cancer-derived cells through suppressing HIF2α expression

Conclusions From our findings we conclude that DBD-F (i) is cytotoxic to gastric cancer-derived cells and (ii) can induce apoptosis in these cells via the MEK/ERK signaling pathway. In addition, our findings strongly indicate that DBD-F can inhibit HIF2α expression by affecting the phosphorylation status of MEK/ERK in gastric cancer-derived cells.
Source: Cellular Oncology - Category: Cancer & Oncology Source Type: research