Acetyl-ed question in mitochondrial biology?

Lysine acetylation on numerous mitochondrial proteins, targeted by the sirtuin deacylase SIRT3, has been proposed to play a major role in regulating diverse mitochondrial functions, particularly in the liver. A new study by Weinert, Choudhary, and colleagues, in this issue of The EMBO Journal, finds that the absolute levels of hepatic mitochondrial protein acetylation in wild-type mice are extremely low and may be insufficient to exert regulatory effects.
Source: EMBO Journal - Category: Molecular Biology Authors: Tags: Metabolism, Post-translational Modifications, Proteolysis & Proteomics News [amp ] Views Source Type: research