Tolerance of ultra-rush immunotherapy in children

Allergen immunotherapy is the only treatment that can treat the cause of the allergy. Rapid desensitization (or ultrarush) allow saving time. However, there are the same tolerance than classic immunotherapy ?We have made a prospective study in the department of pneumology in military hospital of Tunisia. We collected 46 children for a period of one year and falling comparing the safety of sublingual immunotherapy Ultra-Rush (n = 28) with the classical subcutaneous immunotherapy (n = 18).The mean age was 8.21 years ( 3-13 years). We had 32 (69%) male and 14 (30%) female. A family atopy was noted in 22 (47%). Active smoking in 1case (2%).19 patients (41%) had side effects: local for subcutaneous such as erythema in 3 cases (16%), a papule in 2 cases (11%), induration in 1 case (5% ), a subcutaneous nodule in 1case (5%) and no effect in10 cases (55%).For the sublingual : an oral pruritus in 7 cases (25%), lips edema in 2 cases (7%), abdominal pain in 2 case (7%). The systemic effects was found in 11 cases and it was benin such as a general pruritus in 3 cases, 2 cases conjunctivitis, rhinitis in 4 case,a hives in 2 cases, no asthma attack, no edema of Quink or anaphylactic reaction were noted ; 10 case (35%) with the sublingual treatment and only 1 case (5% ) case with subcutaneously treatment.Our study showed an excellent tolerability of sublingual Ultra-Rush, comparable to subcutaneous and studies published in the literature.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: 5.3 Allergy and Immunology Source Type: research