Vitamin D concentration and patient reported outcomes in sarcoidosis

Sarcoidosis patients frequently have low inactive Vitamin D form levels accompanied with the increased levels of the active form due to its autonomic conversion in sarcoid granulomas. The aim of our study was to evaluate the influence of lower serum Vitamin D3 concentration on subjective disease outcomes – fatigue and depression.In the cross-sectional study the degree of fatigue and depression was measured in 400 (27.3% males) patients with pulmonary sarcoidosis. Fatigue was measured by standardized Fatigue Assessment Scale (FAS). Depression was assessed by CES-D instrument.Mean age of patients was 50.5±11 years; average duration of the disease 6.1±6.1 years; mean Vitamin D3 level was 14.2±10.2 µg/L. Mean FAS score was 21.9±6.3. Fatigue (FAS scores ≥ 22) was present in 186 (46.5%) patients. Mean CES-D scoore was 14.4±8.4. Clinically defined depression (CES-D scores ≥ 16) had 128 patients (32%).We found a significant correlation between mean Vitamin D3 levels and physical and mental component of fatigue (p=0.017 and p=0.018, respectively), but the correlation with the total FAS scores was absent. We also noticed a significant correlation between mean Vitamin D levels and CES-D scores (p=0.044). FAS score, Vitamina D3 and symptoms score were highly significant independent predictors of the depression in sarcoidosis patients. A highly significant canonic discriminative function (Wilks' Lambda=0.642; 2=145.22; p
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: 1.13 Clinical Problems - Other Source Type: research

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Conclusion: Without difference of sarcoidosis characteristics, the best respiratory parameter of military population could be explained by more physical training. Scores of anxiety, depression and quality of life scales were significantly more altered in the civilian population, not seem to be attributable with sarcoidosis; we can make hypothesis of possible protective effect of social link in military population, in spite of indisputable factors of stress.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research
Conclusion: Among ILD patients we noted an increased prevalence of depressive and anxiety symptoms. Early detection and specialized management of these disorders must be an integral part of the ILD therapeutic panel
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research
Conclusion: The patients had moderate adaptation. The existence of mental pressures and insolvency of the patients indicated their good prognosis for treatment. Therefore, paying comprehensive attention to somatic diseases is important for promoting somatic and mental treatment of the patients, because neglecting the personality characteristics and psychological factors of the patients would prevent the appropriate treatment of them.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog aka Tropical Travel Trouble 009 The diagnosis of HIV is no longer fatal and the term AIDS is becoming less frequent. In many countries, people with HIV are living longer than those with diabetes. This post will hopefully teach the basics of a complex disease and demystify some of the potential diseases you need to consider in those who are severely immunosuppressed. While trying to be comprehensive this post can not be exhaustive (as you can imagine any patient with ...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Clinical Cases Tropical Medicine AIDS art cryptococcoma cryptococcus HIV HIV1 HIV2 PEP PrEP TB toxoplasma tuberculoma Source Type: blogs
Conclusions: Our results provide the first documented evidence that PR is a promising complementary therapy option for sarcoidosis patients who remain subjectively symptomatic despite optimised outpatient medical treatment.Respiration
Source: Respiration - Category: Respiratory Medicine Source Type: research
This study investigated the effects of an exercise program on functional capacity and quality of life in patients with stage 3 and stage 4 sarcoidosis. Methods: Eighteen patients with stage 3 and 4 sarcoidosis were recruited; 9 received 12 wk of supervised exercise training and 9 received usual care. Patients underwent the following evaluations at baseline and follow-up: 6-min walk test, maximal inspiratory and expiratory pressure tests, back and leg dynamometer test, modified Medical Research Council Dyspnea Scale, Fatigue Severity Scale, St George Respiratory Questionnaire, Short Form-36 Quality of Life Questionnaire,...
Source: Journal of Cardiopulmonary Rehabilitation - Category: Rehabilitation Tags: Pulmonary Rehabilitation Source Type: research
This study investigated the effects of an exercise program on functional capacity and quality of life in patients with stage 3 and stage 4 sarcoidosis. METHODS: Eighteen patients with stage 3 and 4 sarcoidosis were recruited; 9 received 12 wk of supervised exercise training and 9 received usual care. Patients underwent the following evaluations at baseline and follow-up: 6-min walk test, maximal inspiratory and expiratory pressure tests, back and leg dynamometer test, modified Medical Research Council Dyspnea Scale, Fatigue Severity Scale, St George Respiratory Questionnaire, Short Form-36 Quality of Life Questionnair...
Source: Journal of Cardiopulmonary Rehabilitation and Prevention - Category: Rehabilitation Authors: Tags: J Cardiopulm Rehabil Prev Source Type: research
We report a young HIV-positive patient who suffered from progressive multifocal leukoencephalopathy caused by the human John Cunningham virus and showed objective clinical improvement after adding mirtazapine to the treatment regimen, an observation that is supported by the emerging literature. KEYWORDS: Progressive multifocal leukoencephalopathy (PML), acquired immunodeficiency syndrome (AIDS), human immunodeficiency virus (HIV), mirtazapine, highly active antiretroviral therapy (HAART) INTRODUCTION Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by the huma...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Case Report CNS Infections Cognition Current Issue Neurologic Systems and Symptoms Primary Care Psychopharmacology acquired immunodeficiency syndrome (AIDS) highly active antiretroviral therapy (HAART) human immunodeficiency virus (HIV) Source Type: research
In January, 2018, Academic Press published my bookPrecision Medicine and the Reinvention of Human Disease. This book has an excellent " look inside " at itsGoogle book site, which includes the Table of Contents. In addition, I thought it might be helpful to see the topics listed in the Book's index. Note that page numbers followed by f indicate figures, t indicate tables, and ge indicate glossary terms.AAbandonware, 270, 310geAb initio, 34, 48ge, 108geABL (abelson leukemia) gene, 28, 58ge, 95 –97Absidia corymbifera, 218Acanthameoba, 213Acanthosis nigricans, 144geAchondroplasia, 74, 143ge, 354geAcne, 54ge, 1...
Source: Specified Life - Category: Information Technology Tags: index jules berman jules j berman precision medicine Source Type: blogs
Conclusion: Multidisciplinary PR seems to have a long lasting positive effect on psychological distress in patients with sarcoidosis even one year after PR.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Rehabilitation and Chronic Care Source Type: research
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