Immune responses to WT1 in patients with AML or MDS after chemotherapy and allogeneic stem cell transplantation

Abstract Wilms' tumor gene 1 (WT1) is overexpressed in leukemia and WT1‐ derived CD8+ T cell epitopes for immunotherapies targeting WT1 have been defined. Here, we analyzed expression of WT1 in 226 peripheral blood and bone marrow samples from patients with acute myeloid leukemia or myelodysplastic syndrome (AML/MDS) before and after allogeneic stem cell transplantation (SCT). Transcripts were assessed by quantitative Polymerase chain reaction, WT1‐specific CD8+ cytotoxic T cells (CTL) were monitored by tetramer staining and enzyme‐linked immunospot (ELISPOT) assays. Reduction of WT1 levels correlated with a longer survival (p
Source: International Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Article Source Type: research

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A treatment presented at the International Conference of Clinical Oncology in Cyprus last week, led to six out of 10 patients with advanced prostate cancer going into remission.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
[The Herald] The First Lady Auxilia Mnangagwa has intensified cancer screening awareness campaigns with the number of people getting screened for the disease increasing threefold. The Ministry of Health and Child Care has also as a result increased its target for cancer screening from 100 000 to 200 000 this year, with over 60 000 having already been screened from January to date.
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The objective of this study was to investigate serum levels of immunosuppressive cytokines TGF beta 1 and VEGF and count of immune cells in peripheral blood in stage II and III colorectal cancer patients. METHODS: Blood samples were collected from 22 colorectal patients and 25 healthy controls before the start of treatment. All patients were examined by a clinical immunologist to exclude patients with immune disorders and autoimmune diseases. TGF beta 1 and VEGF were measured by ELISA, and anti-tumor cellular immunity cells (CD4, CD8, B cells, NK cells) were measured by flow cytometry. RESULTS: TGF beta 1 and VEGF ...
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
Photochem. Photobiol. Sci., 2018, Advance Article DOI: 10.1039/C8PP00112J, PerspectiveL. Larue, A. Ben Mihoub, Z. Youssef, L. Colombeau, S. Acherar, J. C. Andre, P. Arnoux, F. Baros, M. Vermandel, C. Frochot Photodynamic therapy is a therapeutic option to treat cancer and other diseases. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Doctors want to remind moms to get certain vaccines while pregnant. Whooping cough in particular can be deadly for newborns, but only about 50 percent of pregnant women get the vaccine. (Image credit: Nicole Xu for NPR)
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Authors: Merle H, Donnio A, Jean-Charles A, Guyomarch J, Hage R, Najioullah F, Césaire R, Cabié A Abstract Arboviruses are viral diseases transmitted by mosquitoes and tick bites. They are a major cause of morbidity and sometimes mortality. Their expansion is constant and due in part to climate change and globalization. Mostly found in tropical regions, arboviruses are sometimes the source of epidemics in Europe. Recently, the Chikungunya virus and the Zika virus were responsible for very large epidemics impacting populations that had never been in contact with those viruses. There are currently no ef...
Source: Journal Francais d Ophtalmologie - Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
PANCREATIC cancer symptoms and signs are caused by changes in the pancreas. Cells start to divide abnormally and uncontrollably, possibly forming a tumour. Watch out for these warning signs of the cancer.
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Background: Suicide rates are high among older adults and many conditions have been related to suicide in this population: chronic illnesses, physical disabilities, cancer, social isolation, mental disorders and neurocognitive disorders. Objectiv...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
PANCREATIC cancer symptoms and signs are caused by changes in the pancreas. Cells start to divide abnormally and uncontrollably, possibly forming a tumour. Watch out for these warning signs of the cancer.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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