Is Taking Birth Control Pills A Band-Aid Treatment For PCOS?
I remember in my early training that the first question to ask a patient with polycystic ovary syndrome was: "Are you trying to get pregnant?" If no, hand them the birth control pill. If yes, choose between clomid, a fertility drug, and metformin, an insulin sensitizer. No questions related to lifestyle, stress, nutrition, total toxic burden – there were 29 more patients to get to that day. It turns out, many lifestyle changes have been shown to pull someone out of the metabolic chaos of PCOS, therefore decreasing their chances of developing comorbidities such as diabetes, heart disease, hypertension, sleep apnea, anxiety, depression and infertility. Insulin resistance is one of the root physiological imbalances in most, if not all, PCOS. This is where your pancreas needs to pump out more and more insulin in response to high blood sugar levels. Insulin lowers the blood sugar by storing the glucose in cells. The cells become resistant to the constant insulin and need more to be signaled to lower the blood sugar. When this resistance goes on for a while, you have high insulin and high blood sugar. Incidentally, insulin is a fat storage hormone, concentrating fat in the belly region. High insulin levels can tell the ovaries to make more testosterone. That's why some women with PCOS have symptoms of excess androgens, like dark hairs on the face and belly. Ask for a fasting insulin and fasting glucose level to be drawn, along with a HgbA1C (an average of blood...
In the article “Perioperative hyperglycemia management: An update” (Duggan DW, Carlson K, Umpierrez GE: Anesthesiology 2017; 126:547 –60), there is an error in figure 2. Under “Elective Surgery,” the subcutaneous insulin dosing regimen was erroneously outlined as a duplicate of the continuous IV insulin infusion. The correct figure is below with the correct intraoperative subcutaneous insulin regimen now outlined in theblue box. The original text was correct but the figure did not match.
A new study from the Yale School of Medicine has found that someone's odds of suicidality increased if his or her RLS was severe or very severe, or if they also suffered from depression.
Dr Steven Kahn describes the ongoing RISE studies and urges aggressive treatment of youth despite disappointing results of the pediatric medication study.Endocrine Society
Authors: Rosino A, Ballester I, Tudela J, González-Billalabeitia E Abstract Prostate cancer is the second mortality cause among males with cancer. Patients with metastatic castration resistant prostate cancer (mCRPC) essentially die due to tumor progression in a castration resistance situation. Docetaxel based chemotherapy was the first therapeutic strategy that demonstrated a survival increase, in addition to pain decrease, increase in tumor responses and quality of life benefit, and it currently continues being useful after the incorporation of new therapies for the treatment of mCRPC. Cabazitaxel, a taxan...
CONCLUSIONS: Abiraterone acetate is a new hormonal treatment for metastatic castration resistant prostate cancer both before and after chemotherapy. The results of the available studies demonstrate a significant improvement in terms of efficacy, with a tolerability profile generally acceptable, predictable and manageable, and an improvement in patient's perceived quality of life. PMID: 30319125 [PubMed - in process]
CONCLUSIONS: Over the last decade, the progress in the knowledge of the molecular bases of CRPC has been very relevant. Even though AR alterations are the most frequent and best characterized, anomalies in other pathways have been also identified as important in the biology of CRPC and derived a notable therapeutic development. PMID: 30319124 [PubMed - in process]
Authors: Martínez-Breijo S, Chantada-Abal V, Aller-Rodríguez M, Bohórquez-Cruz M, Sacristán-Lista F, Ponce-Díaz J, Vázquez-Martul D, Lamas-Díaz L Abstract The androgen-signaling axis plays a pivotal role in the pathogenesis of prostate cancer. Since the landmark discovery by Huggins and Hodges, gonadal depletion of androgens has remained a mainstay of therapy for advanced disease. However, invariably progression to castration-resistant prostate cancer (CRPC) occurs within 2-3 years of initiation of ADT. Multiple mechanisms of resistance help contribute to the progres...
Why are there still so many hurdles between obese patients with type 2 diabetes who would benefit from this life-saving treatment?Medscape
SUPPLEMENTS could be sued to improve heart health, as well as to lower the risk of heart attack and high blood pressure symptoms. Add these cheap capsules to your daily diet to lower your chances of heart disease and strokes.
Substance abuse and addiction isn’t just limited to alcohol and street drugs. It can also be very easy to become addicted to medication. This can be very confusing and dangerous all at the same time, because medication has been prescribed to help treat something that might be wrong. While taking medication prescribed by a doctor and following all dosing instructions can be beneficial for many, it can also lead to addiction when tolerance builds and someone begins to take more than the recommended dose. If you feel as if you may be becoming addicted to your medication, read these warning signs below and seek help. Top...
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