Clonal Evolution of Preleukemic hematopoietic stem cells in acute myeloid leukemia
Acute myeloid leukemia (AML) is an aggressive blood cancer that results from an abnormal expansion of uncontrollably proliferating myeloid progenitors that have lost the capacity to differentiate. AML encompasses many genetically distinct subtypes that predominantly develop de novo. However, AML can also arise from premalignant myeloid conditions, such as myelodysplastic syndrome (MDS) and myeloproliferative neoplasms (MPNs), or develop as the result of exposure to genotoxic agents used to treat unrelated malignancies.
Source: Experimental Hematology - Category: Hematology Authors: Stephen M. Sykes, Konstantinos D. Kokkaliaris, Michael D. Milsom, Ross L. Levine, Ravindra Majeti Source Type: research
More News: Acute Leukemia | Acute Myeloid Leukemia | Cancer | Cancer & Oncology | Genetics | Hematology | Leukemia | Myelodysplastic Syndrome | Myeloproliferative Disorders | Stem Cell Therapy | Stem Cells