Recent developments in HLA-haploidentical transplantations

Publication date: Available online 22 October 2015 Source:Best Practice & Research Clinical Haematology Author(s): Margaret Showel, Ephraim J. Fuchs While allogeneic hematopoietic stem cell transplantations have a curative potential, several patients with hematologic malignancies cannot avail themselves of this therapeutic option due to lack of matched donor availability. Although HLA-haploidentical transplantations were previously associated with poor outcomes, recent evidence with use of post transplantation cyclophosphamide indicate improved safety and efficacy. The following paper discusses the most recent developments in this area.
Source: Best Practice and Research Clinical Haematology - Category: Hematology Source Type: research

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CONCLUSIONS: Three repeated administrations of hUCB-MSCs into the lateral ventricle via an Ommaya reservoir were feasible, relatively and sufficiently safe, and well-tolerated. Currently, we are undergoing an extended follow-up study for those who participated in a phase IIa trial where upon completion, we hope to gain a deeper understanding of the clinical efficacy of MSC AD therapy.TRIAL REGISTRATION: ClinicalTrials.gov NCT02054208. Registered on 4 February 2014. ClinicalTrials.gov NCT03172117. Registered on 1 June 2017.PMID:34521461 | DOI:10.1186/s13195-021-00897-2
Source: Cell Research - Category: Cytology Authors: Source Type: research
AbstractAcute myeloid leukemia (AML) relapse after allogeneic stem cell transplant (alloSCT) remains a major therapeutic challenge. While patients with longer remission after initial alloSCT are recommended to receive cell therapy (CT) such as 2ndalloSCT or donor lymphocyte infusion (DLI), survival for patients who relapse within 6  months of alloSCT has been dismal. We evaluated the outcomes of AML relapse after alloSCT to assess the impact of different treatments on long-term survival. One hundred and seventy-two patients with AML underwent alloSCT at the Penn State Cancer Institute from January 2014 to August 2019....
Source: Annals of Hematology - Category: Hematology Source Type: research
Opinion statementMantle cell lymphoma is a rare and incurable non-Hodgkin lymphoma with a heterogenous clinical presentation. Typically, treatment consists of frontline chemoimmunotherapy induction with or without autologous stem cell transplant (ASCT) as consolidation. However, this approach has the propensity to increase short- and long-term toxicities, such as secondary malignancies, without being curative. Genomic profiling of MCL will allow for greater impact of new targeted therapies in the future and may become a helpful tool to guide treatment. Based on the data discussed, use of non-chemotherapy options may become...
Source: Current Treatment Options in Oncology - Category: Cancer & Oncology Source Type: research
The global coronavirus disease-2019 (COVID-19) pandemic has drastically disrupted many aspects of life and healthcare in unparalleled ways. For patients with cancer, it has impacted both treatment and recovery trajectories.1, 2 Patients with hematologic malignancies undergoing hematopoietic stem cell transplantation (HSCT) are especially vulnerable to care changes imposed by the pandemic due to factors associated with HSCT, including the intensive treatment with a prolonged hospitalization, high burden of physical symptoms due to potential toxic side effects, and quality of life (QOL) challenges in recovery.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
Schematic diagram illustrating the major brain regions affected in neurodegenerative diseases, to which EVs actively migrate following IN administration. The figure presents the key mechanisms and cargo used by MSC-derived EVs to mitigate these pathologies and induce regeneration. AbstractNeurological disorders are diseases of the central nervous system (CNS), characterized by a progressive degeneration of cells and deficiencies in neural functions. Mesenchymal stem cells (MSCs) are a promising therapy for diseases and disorders of the CNS. Increasing evidence suggests that their beneficial abilities can be attributed to t...
Source: Stem Cells - Category: Stem Cells Authors: Tags: Regenerative Medicine Source Type: research
Researchers from Nantes University Hospital found that people who receive stem cell transplants are likely to develop high antibody responses to the COVID-19 vaccines, even after only one shot.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Aging (Albany NY). 2021 Sep 14;13(undefined). doi: 10.18632/aging.203524. Online ahead of print.ABSTRACTWe investigated the influence of signal transducer and activator of transcription-3 (STAT3) on the spinal cord tissue grafts of rat fetuses with spina bifida aperta. In particular, we hoped to identify whether transfection of the STAT3 overexpression plasmid increases the survival of spinal cord transplantation in order to improve therapeutic efficacy. The fetal rat model of spina bifida aperta was established using retinoic acid and treated with a microsurgical injection of bone marrow mesenchymal stem cells (BMSCs). Th...
Source: Aging - Category: Biomedical Science Authors: Source Type: research
Conclusion The audit revealed that the current psychology service provision is failing to meet the international standards of care. Due to the data provided by this audit, in conjunction with a clinical risk assessment of the service, funds for the post of principal psychologist have been secured. Further psychology posts (HSCT, late-effects and neuropsychology), and development of the psycho-oncology model of care are required to ensure equality of access and evidence-based psychological care for all children with cancer.PMID:34520155
Source: Ir Med J - Category: General Medicine Authors: Source Type: research
Conclusions In non-transplanted patients, CED ≥ 7200 mg/m2 was associated with a DOR, while younger age at diagnosis played a protective role on ovarian reserve. As a result of the data collected, we propose a systematic algorithm to assess iatrogenic gonadal impairment in young female patients exposed to chemo-radiotherapy in childhood for hematological disorders.PMID:34519276 | DOI:10.1530/EJE-21-0351
Source: European Journal of Endocrinology - Category: Endocrinology Authors: Source Type: research
AbstractMixed phenotype acute leukemia (MPAL) is an uncommon disease characterized by currently only limited knowledge concerning biology, clinical presentation, and treatment outcome. We here describe a most unusual case of simultaneous occurrence of T-lymphoblastic lymphoma in cervical and mediastinal lymph nodes and acute myeloid leukemia in the bone marrow (BM) successfully treated with allogeneic stem cell transplantation (SCT). Although the blasts in both locations showed additional aberrant expression of other lineage markers (even B-cell markers), diagnostic criteria of MPAL were not fulfilled either in the LN or i...
Source: Journal of Hematopathology - Category: Pathology Source Type: research
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