Molecular Investigation into a Malaria Outbreak in Cusco, Peru: Plasmodium falciparum BV1 Lineage is Linked to a Second Outbreak in Recent Times.

Molecular Investigation into a Malaria Outbreak in Cusco, Peru: Plasmodium falciparum BV1 Lineage is Linked to a Second Outbreak in Recent Times.
Am J Trop Med Hyg. 2015 Oct 19;
Authors: Okoth SA, Chenet SM, Arrospide N, Gutierrez S, Cabezas C, Matta JA, Udhayakumar V
Abstract
In November 2013, a Plasmodium falciparum malaria outbreak of 11 cases occurred in Cusco, southern Peru, where falciparum malaria had not been reported since 1946. Although initial microscopic diagnosis reported only Plasmodium vivax infection in each of the specimens, subsequent examination by the national reference laboratory confirmed P. falciparum infection in all samples. Molecular typing of four available isolates revealed identity to the B-variant (BV1) strain that was responsible for a malaria outbreak in Tumbes, northern Peru, between 2010 and 2012. The P. falciparum BV1 strain is multidrug resistant, can escape detection by PfHRP2-based RDTs, and has contributed to two malaria outbreaks in Peru. This investigation highlights the importance of accurate species diagnosis given the potential for P. falciparum to be reintroduced to regions where it may have been absent. Similar molecular epidemiological investigations can track the probable source(s) of outbreak parasite strains for malaria surveillance and control purposes.
PMID: 26483121 [PubMed - as supplied by publisher]

Source: The American Journal of Tropical Medicine and Hygiene - October 19, 2015 Category: Tropical Medicine Authors: Okoth SA, Chenet SM, Arrospide N, Gutierrez S, Cabezas C, Matta JA, Udhayakumar V Tags: Am J Trop Med Hyg Source Type: research