Ablation of HRC alleviates cardiac arrhythmia and improves abnormal Ca handling in CASQ2 knockout mice prone to CPVT

Conclusion
Our results suggest that rather than being functionally redundant, CASQ2 and HRC modulate cardiac ryanodine receptor-mediated (RyR2) Ca release in an opposing manner. In particular, while CASQ2 stabilizes RyR2 rendering it refractory in the diastolic phase, HRC enhances RyR2 activity facilitating RyR2 recovery from refractoriness.

Source: Cardiovascular Research - October 22, 2015 Category: Cardiology Authors: Liu, B., Ho, H.-T., Brunello, L., Unudurthi, S. D., Lou, Q., Belevych, A. E., Qian, L., Kim, D. H., Cho, C., Janssen, P. M. L., Hund, T. J., Knollmann, B. C., Kranias, E. G., Gyorke, S. Tags: Ion Channels and Arrhythmias Source Type: research