Gadd45{gamma} regulates cardiomyocyte death and post-myocardial infarction left ventricular remodelling
Conclusion
This work is the first to demonstrate that Gadd45 accumulation during MI promotes the development and persistence of HF by inducing cardiomyocyte apoptosis in a p38 MAPK-dependent manner. We clearly identify Gadd45 as a therapeutic target in the development of HF.
Source: Cardiovascular Research - Category: Cardiology Authors: Lucas, A., Mialet-Perez, J., Daviaud, D., Parini, A., Marber, M. S., Sicard, P. Tags: Cardiac biology and remodelling Source Type: research
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