Gadd45{gamma} regulates cardiomyocyte death and post-myocardial infarction left ventricular remodelling

Conclusion This work is the first to demonstrate that Gadd45 accumulation during MI promotes the development and persistence of HF by inducing cardiomyocyte apoptosis in a p38 MAPK-dependent manner. We clearly identify Gadd45 as a therapeutic target in the development of HF.
Source: Cardiovascular Research - Category: Cardiology Authors: Tags: Cardiac biology and remodelling Source Type: research